Topors Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Topors
topoisomerase I binding, arginine/serine-rich
MGI:2146189

32 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Topors^em1(IMPC)J/Topors^em1(IMPC)J C57BL/6NJ-Topors^em1(IMPC)J/Mmjax	abnormal auditory brainstem response	J:211773
	cataract	J:211773
	cornea opacity	J:211773
	decreased bone mineral content	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased heart rate	J:211773
	decreased heart weight	J:211773
	decreased hematocrit	J:211773
	decreased lean body mass	J:211773
	female infertility	J:211773
	hyperactivity	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating glucose level	J:211773
	increased total body fat amount	J:211773
	increased vertical activity	J:211773
	prolonged QT interval	J:211773
	prolonged RR interval	J:211773
Topors^{Gt(DTM034)Byg}/Topors⁺ involves: 129P2/OlaHsd * C57BL/6J	normal cellular phenotype	J:325276
	increased tumor incidence	J:325276
Topors^{Gt(DTM034)Byg}/Topors^{Gt(DTM034)Byg} involves: 129P2/OlaHsd * C57BL/6J	abnormal fibroblast physiology	J:325276
	abnormal mitosis	J:325276
	aneuploidy	J:325276
	decreased body size	J:325276
	decreased body weight	J:325276
	decreased fibroblast proliferation	J:325276
	kyphosis	J:325276
	normal neoplasm	J:325276
	perinatal lethality, incomplete penetrance	J:325276
	premature death	J:325276
	normal reproductive system phenotype	J:325276

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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