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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ift140
intraflagellar transport 140
MGI:2146906
88 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ift140b2b1283Clo/Ift140b2b1283Clo
C57BL/6J-Ift140b2b1283Clo 		abnormal aortic arch morphology J:175213
absent spleen J:175213
atrioventricular septal defect J:175213
cleft palate J:175213
kidney cyst J:175213
left pulmonary isomerism J:175213
persistent truncus arteriosus J:175213
polydactyly J:175213
right aortic arch J:175213
Ift140cauli/Ift140cauli
involves: C3H/HeH * C57BL/6JAnu 		abnormal atrioventricular valve morphology J:220659
abnormal costovertebral joint morphology J:220659
abnormal craniofacial morphology J:199856, J:220659
abnormal digit morphology J:220659
abnormal exoccipital bone morphology J:220659
abnormal heart looping J:199856
abnormal heart ventricle morphology J:220659
abnormal interventricular septum morphology J:220659
abnormal limb bud morphology J:220659
abnormal lung morphology J:220659
abnormal maxilla morphology J:220659
abnormal mouth morphology J:220659
abnormal neural tube closure J:220659
abnormal neural tube morphology J:220659
abnormal primary cilium morphology J:220659
abnormal rib morphology J:220659
abnormal somite development J:220659
abnormal tricuspid valve morphology J:220659
absent alisphenoid bone J:220659
absent facial bone J:220659
absent neurocranium J:220659
absent palatine bone J:220659
absent tympanic ring J:220659
anophthalmia J:199856, J:220659
cervical vertebral fusion J:220659
curly tail J:220659
exencephaly J:199856, J:220659
exostosis J:220659
facial bone hypoplasia J:220659
forelimb oligodactyly J:199856, J:220659
fusion of atlas and occipital bones J:220659
heart hemorrhage J:220659
hydrops fetalis J:220659
lethality throughout fetal growth and development, complete penetrance J:220659
lethality throughout fetal growth and development, incomplete penetrance J:199856
maxilla hypoplasia J:220659
omphalocele J:220659
palatal shelf hypoplasia J:220659
polydactyly J:199856, J:220659
premaxilla hypoplasia J:220659
prenatal growth retardation J:220659
rib bifurcation J:220659
spina bifida J:199856
Ift140tm1b(KOMP)Wtsi/Ift140tm1b(KOMP)Wtsi
B6.B6N-Ift140tm1b(KOMP)Wtsi 		embryonic lethality, complete penetrance J:181533
Ift140tm1b(KOMP)Wtsi/Ift140tm1b(KOMP)Wtsi
involves: C57BL/6N 		abnormal hindlimb bud morphology J:220659
abnormal mouth morphology J:220659
embryonic lethality during organogenesis, complete penetrance J:220659
exencephaly J:220659
Ift140tm1b(KOMP)Wtsi/Ift140tm1c(KOMP)Wtsi
Tg(Hoxb7-cre)13Amc/?
B6J.B6-Ift140tm1b(KOMP)Wtsi/Ift140tm1c(Komp)Wtsi Tg(Hoxb7-cre)13Amc 		abnormal kidney collecting duct morphology J:181533
abnormal kidney morphology J:181533
abnormal kidney physiology J:181533
normal cellular phenotype J:181533
decreased kidney epithelial cell primary cilium length J:181533
dilated kidney collecting duct J:181533
increased kidney apoptosis J:181533
increased kidney cell proliferation J:181533
kidney cortex cyst J:181533
kidney cyst J:181533
kidney failure J:181533
kidney medulla cyst J:181533
renal fibrosis J:181533
Ift140tm1c(KOMP)Wtsi/Ift140tm1c(KOMP)Wtsi
Tg(Stra8-icre)1Reb/0
involves: C57BL/6N * FVB/NJ 		abnormal manchette morphology J:285527
abnormal outer dense fiber morphology J:285527
abnormal sperm axoneme morphology J:285527
abnormal sperm end piece morphology J:285527
abnormal sperm fibrous sheath morphology J:285527
abnormal sperm flagellum morphology J:285527
abnormal sperm head morphology J:285527
abnormal sperm mitochondrial morphology J:285527
abnormal sperm nucleus morphology J:285527
abnormal spermatid morphology J:285527
abnormal spermiation J:285527
abnormal spermiogenesis J:285527
asthenozoospermia J:285527
decreased sperm progressive motility J:285527
immotile sperm J:285527
impaired fertilization J:285527
kinked sperm flagellum J:285527
male infertility J:285527
oligozoospermia J:285527
normal reproductive system phenotype J:285527
short sperm flagellum J:285527
teratozoospermia J:285527
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory