Ticam1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ticam1
TIR domain containing adaptor molecule 1
MGI:2147032

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ifih1^tm1Aki/Ifih1^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki involves: 129P2/OlaHsd	abnormal interferon level	J:137522
	abnormal interleukin level	J:137522
Irak4^m1Btlr/Irak4^m1Btlr Ticam1^Lps2/Ticam1^Lps2 involves: C57BL/6J	decreased tumor necrosis factor secretion	J:187583
Mavs^tm1Aki/Mavs^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki involves: 129P2/OlaHsd * C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:130954
	decreased circulating interferon-alpha level	J:130954
	decreased circulating interferon-beta level	J:130954
	decreased circulating interferon-gamma level	J:130954
	decreased circulating interleukin-6 level	J:130954
	decreased circulating interleukin-12b level	J:130954
	decreased cytotoxic T cell cytolysis	J:130954
	decreased IgG1 level	J:130954
	decreased IgG2a level	J:130954
	decreased IgG level	J:130954
	decreased interferon-beta secretion	J:130954
	decreased interleukin-12b secretion	J:130954
Myd88^tm1Aki/Myd88^tm1Aki Ticam1^tm1Aki/Ticam1⁺ B6.129P2-Myd88^tm1Aki Ticam1^tm1Aki	decreased macrophage cytokine production	J:140485
	decreased macrophage nitric oxide production	J:140485
	increased susceptibility to parasitic infection	J:140485
	increased susceptibility to parasitic infection induced morbidity/mortality	J:140485
Myd88^tm1Aki/Myd88^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki B6.129P2-Myd88^tm1Aki Ticam1^tm1Aki	decreased macrophage cytokine production	J:140485
	decreased macrophage nitric oxide production	J:140485
	increased susceptibility to parasitic infection	J:140485
	increased susceptibility to parasitic infection induced morbidity/mortality	J:140485
Myd88^tm1Aki/Myd88^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki involves: 129P2/OlaHsd	abnormal dendritic cell physiology	J:174941
	abnormal macrophage physiology	J:174941
Ptpn6^m1Btlr/Ptpn6^m1Btlr Ticam1^Lps2/Ticam1^Lps2 C57BL/6J-Ptpn6^m1Btlr Ticam1^Lps2	ulcerated autopod	J:142845
Ripk3^tm2Vmd/Ripk3^tm2Vmd Ticam1^tm1Aki/Ticam1^tm1Aki involves: 129P2/OlaHsd * C57BL/6N	embryonic lethality prior to tooth bud stage	J:209137
Ticam1^Lps2/Ticam1^Lps2 Myd88^tm1Aki/Myd88^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal macrophage physiology	J:84896
	decreased tumor necrosis factor secretion	J:84896
Ticam1^tm1Tsse/Ticam1^tm1Tsse Tg(PVR)1Kkst/0 involves: 129 * C57BL/6 * ICR	abnormal interferon-alpha secretion	J:179625
	increased susceptibility to Picornaviridae infection	J:179625
	increased susceptibility to Picornaviridae infection induced morbidity/mortality	J:179625

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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