Otub1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Otub1
OTU domain, ubiquitin aldehyde binding 1
MGI:2147616

29 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Otub1^tm1Ama/Otub1^tm1Ama C57BL/6J-Otub1^tm1Ama	lethality throughout fetal growth and development, complete penetrance	J:267520
Otub1^{tm1b(EUCOMM)Hmgu}/Otub1⁺ C57BL/6N-Otub1^{tm1b(EUCOMM)Hmgu}/H	abnormal cranium morphology	J:211773
	abnormal heart position or orientation	J:211773
	abnormal lung morphology	J:211773
	decreased grip strength	J:211773
Otub1^{tm1b(EUCOMM)Hmgu}/Otub1⁺ C57BL/6N-Otub1^{tm1b(EUCOMM)Hmgu}/Ics	decreased bone mineral content	J:211773
	decreased exploration in new environment	J:211773
	increased cornea thickness	J:211773
Otub1^{tm1b(EUCOMM)Hmgu}/Otub1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Otub1^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773
Otub1^{tm1b(EUCOMM)Hmgu}/Otub1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Otub1^{tm1b(EUCOMM)Hmgu}/Ics	preweaning lethality, complete penetrance	J:211773
Otub1^{tm1c(EUCOMM)Hmgu}/Otub1^{tm1c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	abnormal B cell activation	J:280549
	abnormal follicular B cell morphology	J:280549
	decreased B-1 B cell number	J:280549
	decreased immature B cell number	J:280549
	decreased T cell number	J:280549
	enlarged spleen	J:280549
	increased anti-double stranded DNA antibody level	J:280549
	increased anti-nuclear antigen antibody level	J:280549
	increased B cell number	J:280549
	increased B-2 B cell number	J:280549
	increased circulating interleukin-6 level	J:280549
	increased IgA level	J:280549
	increased IgG2a level	J:280549
	increased IgG2b level	J:280549
	increased IgM level	J:280549
	increased immunoglobulin level	J:280549
	increased marginal zone B cell number	J:280549
	increased mature B cell number	J:280549
	increased susceptibility to autoimmune disorder	J:280549
	increased susceptibility to systemic lupus erythematosus	J:280549

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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