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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
MGI:2147834
47 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc6a8tm1.1Clar/Y
Tg(Camk2a-cre)2Gsc/0
involves: C57BL/6 * C57BL/6J * FVB/N 		abnormal response to novel object J:190081
abnormal spatial learning J:190081
abnormal spatial reference memory J:190081
abnormal spatial working memory J:190081
normal behavior/neurological phenotype J:190081
decreased creatine level J:190081
decreased percent body fat/body weight J:190081
hyperactivity J:190081
increased urine creatine level J:190081
Slc6a8tm1.1Lbar/Y
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL 		abnormal dentate gyrus morphology J:238578
abnormal neuron proliferation J:238578
abnormal object recognition memory J:238578
abnormal spatial working memory J:238578
decreased creatine level J:238578
impaired long-term object recognition memory J:238578
impaired short-term object recognition memory J:238578
Slc6a8tm1.2Clar/Y
involves: BALB/cJ * C57BL/6 * C57BL/6J * SJL 		abnormal spatial learning J:169472
normal behavior/neurological phenotype J:169472
decreased body weight J:169472
decreased circulating creatine level J:169472
decreased creatine level J:169472
decreased locomotor activity J:169472
hyperactivity J:169472
impaired contextual conditioning behavior J:169472
impaired short-term object recognition memory J:169472
impaired swimming J:169472
increased serotonin level J:169472
Slc6a8tm1.2Lbar/Y
involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N 		abnormal dentate gyrus morphology J:238578
abnormal GABAergic neuron morphology J:238578
abnormal neuron proliferation J:238578
abnormal object recognition memory J:238578
abnormal spatial reference memory J:238578
abnormal spatial working memory J:238578
abnormal synapse morphology J:238578
decreased body weight J:238578
decreased creatine level J:238578
decreased hippocampus volume J:238578
impaired coordination J:238578
impaired long-term object recognition memory J:238578
impaired short-term object recognition memory J:238578
increased grooming behavior J:238578
lipofuscinosis J:238578
microgliosis J:238578
Slc6a8tm1.2Lbar/Y
involves: 129 * 129S1/Sv * C57BL/6N 		abnormal object recognition memory J:232606
abnormal spatial reference memory J:232606
abnormal spatial working memory J:232606
decreased body weight J:232606
decreased circulating creatine level J:232606
decreased creatine level J:232606
decreased locomotor activity J:232606
decreased urine creatine level J:232606
impaired spatial learning J:232606
impaired swimming J:232606
Slc6a8tm1e(KOMP)Wtsi/Y
involves: C57BL/6J * C57BL/6N 		abnormal enzyme/coenzyme activity J:264220
abnormal ion homeostasis J:264220
abnormal motor learning J:264220
abnormal muscle morphology J:264220
abnormal muscle physiology J:264220
decreased aerobic running capacity J:264220
decreased body length J:264220
decreased body mass index J:264220
decreased body weight J:264220
decreased circulating glucose level J:264220
decreased creatine level J:264220
decreased fasting circulating glucose level J:264220
decreased grip strength J:264220
hypotonia J:264220
improved glucose tolerance J:264220
increased lean body mass J:264220
kyphoscoliosis J:264220
kyphosis J:264220
muscle weakness J:264220
skeletal muscle fiber atrophy J:264220
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory