Foxp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxp2
forkhead box P2
MGI:2148705

58 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxp2^N549K/Foxp2^N549K involves: BALB/c * C3H/HeH	abnormal cerebellar foliation	J:135404
	abnormal righting response	J:135404
	premature death	J:135404
	slow postnatal weight gain	J:135404
	small cerebellum	J:135404
Foxp2^R552H/Foxp2⁺ involves: BALB/c * C3H/HeH	abnormal motor learning	J:135404
	enhanced paired-pulse facilitation	J:135404
	reduced long-term depression	J:135404
Foxp2^R552H/Foxp2^R552H involves: BALB/c * C3H/HeH	abnormal righting response	J:135404
	abnormal vocalization	J:135404
	premature death	J:135404
	reduced cerebellar foliation	J:135404
	slow postnatal weight gain	J:135404
	small cerebellum	J:135404
Foxp2^S321X/Foxp2^S321X involves: C3HeB/FeJ	abnormal righting response	J:135404
	premature death	J:135404
	reduced cerebellar foliation	J:135404
	slow postnatal weight gain	J:135404
	small cerebellum	J:135404
Foxp2^tm1Bux/Foxp2⁺ involves: C57BL/6	abnormal cerebellum external granule cell layer morphology	J:99864
	abnormal radial glial cell morphology	J:99864
	decreased vocalization	J:99864
	postnatal growth retardation	J:99864
Foxp2^tm1Bux/Foxp2^tm1Bux involves: 129X1/SvJ * C57BL/6	abnormal respiratory conducting tube morphology	J:121421
	impaired lung alveolus development	J:121421
	overexpanded pulmonary alveolus	J:121421
Foxp2^tm1Bux/Foxp2^tm1Bux involves: C57BL/6	abnormal cerebellar Purkinje cell layer	J:99864
	abnormal cerebellum external granule cell layer morphology	J:99864
	abnormal Purkinje cell dendrite morphology	J:99864
	abnormal radial glial cell morphology	J:99864
	abnormal reflex	J:99864
	decreased locomotor activity	J:99864
	decreased vocalization	J:99864
	delayed ear emergence	J:99864
	delayed eyelid opening	J:99864
	impaired righting response	J:99864
	positive geotaxis	J:99864
	postnatal growth retardation	J:99864
	postnatal lethality, complete penetrance	J:99864
	thin cerebellar molecular layer	J:99864
Foxp2^tm1Momo/Foxp2⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal vocalization	J:132813
Foxp2^tm1Momo/Foxp2⁺ involves: 129S6/SvEvTac * C57BL/6	decreased body weight	J:132813
Foxp2^tm1Momo/Foxp2^tm1Momo involves: 129S6/SvEvTac * C57BL/6	abnormal cerebellar foliation	J:132813
	abnormal cerebellar Purkinje cell layer	J:132813
	abnormal cerebellum morphology	J:132813
	abnormal motor capabilities/coordination/movement	J:132813
	abnormal Purkinje cell dendrite morphology	J:132813
	bradykinesia	J:132813
	decreased body size	J:132813
	decreased body weight	J:132813
	decreased brain size	J:132813
	decreased vocalization	J:132813
	embryonic lethality, incomplete penetrance	J:132813
	impaired righting response	J:132813
	perinatal lethality, incomplete penetrance	J:132813
	postnatal growth retardation	J:132813
	small cerebellum	J:132813
Foxp2^tm1Sfis/Foxp2^tm1.2Sfis Edil3^{Tg(Sox2-cre)1Amc}/? involves: C57BL/6 * CBA * SJL	decreased body weight	J:125023
	delayed eyelid opening	J:125023
	impaired righting response	J:125023
	lethality at weaning, complete penetrance	J:125023
	reduced cerebellar foliation	J:125023
	small cerebellum	J:125023
Foxp2^tm2.1Woen/Foxp2^tm2.1Woen involves: C57BL/6 * C57BL/6J * SJL	abnormal dendrite morphology	J:150425
	abnormal long-term depression	J:150425
	abnormal neurite morphology	J:150425
	abnormal synaptic plasticity	J:150425
	normal cardiovascular system phenotype	J:150425
	decreased dopamine level	J:150425
	decreased exploration in new environment	J:150425
	decreased vocalization	J:150425
Foxp2^tm2.2Woen/Foxp2⁺ involves: C57BL/6 * C57BL/6J	abnormal cardiovascular system physiology	J:150425
	abnormal circulating mineral level	J:150425
	abnormal eating behavior	J:150425
	abnormal energy homeostasis	J:150425
	abnormal response to novel object	J:150425
	decreased exploration in new environment	J:150425
	decreased lean body mass	J:150425
	decreased startle reflex	J:150425
	decreased total fat pad weight	J:150425
	impaired coordination	J:150425
	increased CD4-positive, alpha-beta T cell number	J:150425
	increased CD8-positive, alpha-beta T cell number	J:150425
	increased circulating ferritin level	J:150425
	increased dopamine level	J:150425
	increased pulmonary respiratory rate	J:150425
	increased serotonin level	J:150425

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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