Ehmt2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ehmt2
euchromatic histone lysine N-methyltransferase 2
MGI:2148922

47 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alpl^tm1(cre)Nagy/Alpl⁺ Ehmt2^tm2Yshk/Ehmt2^tm2.1Yshk involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal female meiosis	J:123269
	abnormal fertility/fecundity	J:123269
	abnormal gametogenesis	J:123269
	arrest of male meiosis	J:123269
	azoospermia	J:123269
	decreased litter size	J:123269
	decreased male germ cell number	J:123269
	decreased oocyte number	J:123269
	female infertility	J:123269
	male infertility	J:123269
	small testis	J:123269
Ehmt2^Gt(ES62)Feil/Ehmt2^Gt(ES62)Feil involves: 129P2/OlaHsd * C57BL/6	abnormal imprinting	J:130398
	decreased embryo size	J:130398
	decreased trophoblast giant cell number	J:130398
	open neural tube	J:130398
	prenatal lethality, complete penetrance	J:130398
	small placenta	J:130398
Ehmt2^{tm1.1(KOMP)Mbp}/Ehmt2⁺ C57BL/6N-Ehmt2^{tm1.1(KOMP)Mbp}/J	abnormal locomotor behavior	J:211773
	decreased exploration in new environment	J:211773
	hyperactivity	J:211773
Ehmt2^{tm1.1(KOMP)Mbp}/Ehmt2^{tm1.1(KOMP)Mbp} C57BL/6N-Ehmt2^{tm1.1(KOMP)Mbp}/J	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Ehmt2^tm1.1Cza/Ehmt2^tm1.1Cza Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2 * SJL	decreased IgG1 level	J:160938
	decreased interleukin-4 secretion	J:160938
	increased IgG2a level	J:160938
	increased interferon-gamma secretion	J:160938
	increased susceptibility to parasitic infection	J:160938
Ehmt2^tm1.1Cza/Ehmt2^tm1.1Cza Tg(VAV1-cre)1Graf/0 involves: C57BL/6 * SJL	abnormal intestinal goblet cell morphology	J:160938
	decreased interleukin-4 secretion	J:160938
	decreased interleukin-5 secretion	J:160938
	decreased interleukin-13 secretion	J:160938
	increased interferon-gamma secretion	J:160938
	increased interleukin-17 secretion	J:160938
	increased susceptibility to parasitic infection	J:160938
Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Camk2a-cre)2Gsc/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal liquid preference	J:155739
	decreased anxiety-related response	J:155739
	decreased exploration in new environment	J:155739
	decreased locomotor activity	J:155739
	decreased vertical activity	J:155739
	impaired behavioral response to xenobiotic	J:155739
	normal nervous system phenotype	J:155739
	obese	J:155739
Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd1-cre)EY262Gsat/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	decreased locomotor activity	J:155739
	impaired behavioral response to xenobiotic	J:155739
	normal nervous system phenotype	J:155739
Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd2-cre)ER44Gsat/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal neuron physiology	J:155739
	enhanced behavioral response to xenobiotic	J:155739
	induced hyperactivity	J:155739
Ehmt2^tm1Bzhu/Ehmt2^tm1Bzhu involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:219788
Ehmt2^tm1Yshk/Ehmt2^tm1Yshk B6.Cg-Ehmt2^tm1Yshk	abnormal apoptosis	J:77998
	abnormal cell physiology	J:77998
	embryonic growth arrest	J:77998
	embryonic lethality during organogenesis, complete penetrance	J:77998
Ehmt2^tm1Yshk/Ehmt2^tm1Yshk involves: C57BL/6 * CBA	embryonic growth arrest	J:77998
Ehmt2^tm1Yshk/Ehmt2^tm1Yshk involves: C57BL/6 * CBA	embryonic lethality during organogenesis, complete penetrance	J:77998

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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