Dock2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dock2
dedicator of cyto-kinesis 2
MGI:2149010

54 phenotypes from 21 alleles in 22 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dock2^m1Anu/Dock2^m1Anu C57BL/6JAnu-Dock2^m1Anu	decreased B cell number	J:104190
Dock2^m1Anu/Dock2^m1Anu C57BL/6JAnu-Dock2^m1Anu	decreased T cell number	J:104190
Dock2^m1Btlr/Dock2^m1Btlr involves: C57BL/6J	abnormal B cell differentiation	J:173592
	abnormal class switch recombination	J:185495
	abnormal humoral immune response	J:173592
	decreased B cell number	J:185495
	decreased IgG level	J:185495
	decreased T cell number	J:185495
	normal immune system phenotype	J:185495
Dock2^m2Anu/Dock2^m2Anu C57BL/6JAnu-Dock2^m2Anu	abnormal T cell morphology	J:104190
	decreased mature B cell number	J:104190
	decreased T cell number	J:104190
Dock2^m2Btlr/Dock2^m2Btlr C57BL/6J-Dock2^m2Btlr	abnormal humoral immune response	J:173670
	decreased B cell number	J:173670
	decreased CD4-positive, alpha-beta T cell number	J:173670
	decreased CD8-positive, alpha-beta T cell number	J:173670
Dock2^m2Btlr/Dock2^m2Btlr involves: C57BL/6J	abnormal B cell differentiation	J:185495
	abnormal class switch recombination	J:185495
	abnormal humoral immune response	J:185495
	decreased B cell number	J:185495
	decreased IgG level	J:185495
	decreased T cell number	J:185495
	normal immune system phenotype	J:185495
Dock2^m3Anu/Dock2^m3Anu C57BL/6NCrlAnu-Dock2^m3Anu	abnormal CD4-positive, alpha beta T cell morphology	J:104190
	abnormal CD8-positive, alpha beta T cell morphology	J:104190
	decreased CD4-positive, alpha-beta T cell number	J:104190
Dock2^m3Btlr/Dock2^m3Btlr C57BL/6J-Dock2^m3Btlr	abnormal CD4-positive T cell differentiation	J:191187
	abnormal CD8-positive, alpha-beta T cell differentiation	J:191187
	abnormal humoral immune response	J:191187
	abnormal immune system physiology	J:191187
	decreased CD4-positive, alpha-beta T cell number	J:191187
	decreased CD8-positive, alpha-beta T cell number	J:191187
Dock2^m4Btlr/Dock2^m4Btlr C57BL/6J-Dock2^m4Btlr	abnormal B cell differentiation	J:221486
	abnormal CD4-positive T cell differentiation	J:221486
	abnormal CD8-positive, alpha-beta T cell differentiation	J:221486
Dock2^m5Btlr/Dock2⁺ C57BL/6J-Dock2^m5Btlr	abnormal CD4-positive T cell differentiation	J:225938
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225938
	decreased CD4-positive, alpha-beta T cell number	J:225938
	decreased single-positive T cell number	J:225938
	impaired hematopoiesis	J:225938
	increased CD8-positive, alpha-beta T cell number	J:225938
	increased single-positive T cell number	J:225938
Dock2^m5Btlr/Dock2^m5Btlr C57BL/6J-Dock2^m5Btlr	abnormal B cell differentiation	J:225938
	abnormal CD4-positive T cell differentiation	J:225938
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225938
	decreased CD4-positive, alpha-beta T cell number	J:225938
	decreased single-positive T cell number	J:225938
	impaired hematopoiesis	J:225938
	increased B cell number	J:225938
	increased CD8-positive, alpha-beta T cell number	J:225938
	increased single-positive T cell number	J:225938
Dock2^m6Btlr/Dock2^m6Btlr C57BL/6J-Dock2^m6Btlr	decreased IgE level	J:236689
Dock2^m6Btlr/Dock2^m6Btlr C57BL/6J-Dock2^m6Btlr	decreased response to antigen	J:236689
Dock2^m7Btlr/Dock2⁺ C57BL/6J-Dock2^m7Btlr	decreased B cell number	J:255181
	increased macrophage cell number	J:255181
	increased neutrophil cell number	J:255181
Dock2^m7Btlr/Dock2^m7Btlr C57BL/6J-Dock2^m7Btlr	decreased B cell number	J:255181
	increased IgE level	J:255181
	increased macrophage cell number	J:255181
	increased neutrophil cell number	J:255181
	increased NK cell number	J:255181
Dock2^m8Btlr/Dock2^m8Btlr C57BL/6J-Dock2^m8Btlr	decreased CD4-positive, alpha-beta T cell number	J:272402
Dock2^m8Btlr/Dock2^m8Btlr C57BL/6J-Dock2^m8Btlr	increased CD8-positive, alpha-beta T cell number	J:272402
Dock2^M9Btlr/Dock2^M9Btlr C57BL/6J-Dock2^M9Btlr	increased CD8-positive, alpha-beta T cell number	J:272403
Dock2^m10Btlr/Dock2^m10Btlr C57BL/6J-Dock2^m10Btlr	decreased B-1b cell number	J:272404
Dock2^m10Btlr/Dock2^m10Btlr C57BL/6J-Dock2^m10Btlr	increased NK cell number	J:272404
Dock2^m11Btlr/Dock2^m11Btlr C57BL/6J-Dock2^m11Btlr	abnormal B cell differentiation	J:272405
	abnormal CD4-positive T cell differentiation	J:272405
	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:272405
	decreased B cell number	J:272405
	decreased CD4-positive, alpha-beta T cell number	J:272405
	decreased CD8-positive, naive alpha-beta T cell number	J:272405
	decreased NK cell number	J:272405
	increased B-1 B cell number	J:272405
	increased CD8-positive, alpha-beta T cell number	J:272405
	increased central memory CD4-positive, alpha-beta T cell number	J:272405
	increased central memory CD8 positive, alpha-beta T cell number	J:272405
	increased effector memory CD4-positive, alpha-beta T cell number	J:272405
Dock2^M12Btlr/Dock2^M12Btlr C57BL/6J-Dock2^M12Btlr	decreased B-1a cell number	J:272406
Dock2^m13Btlr/Dock2^m13Btlr C57BL/6J-Dock2^m13Btlr	increased alpha-beta T cell number	J:272437
Dock2^m13Btlr/Dock2^m13Btlr C57BL/6J-Dock2^m13Btlr	increased CD8-positive, alpha-beta T cell number	J:272437
Dock2^M14Btlr/Dock2^M14Btlr C57BL/6J-Dock2^M14Btlr	abnormal lymphocyte morphology	J:272438
Dock2^M14Btlr/Dock2^M14Btlr C57BL/6J-Dock2^M14Btlr	increased CD8-positive, alpha-beta T cell number	J:272438
Dock2^m15Btlr/Dock2^m15Btlr C57BL/6J-Dock2^m15Btlr	decreased B cell number	J:274942
	decreased CD4-positive, alpha-beta T cell number	J:274942
	decreased CD8-positive, naive alpha-beta T cell number	J:274942
	decreased T cell number	J:274942
	increased B-1 B cell number	J:274942
	increased CD8-positive, alpha-beta T cell number	J:274942
	increased central memory CD8 positive, alpha-beta T cell number	J:274942
	increased NK cell number	J:274942
Dock2^M16Btlr/Dock2^M16Btlr C57BL/6J-Dock2^M16Btlr	abnormal CD8-positive, alpha-beta T cell number	J:274971
Dock2^{tm1b(EUCOMM)Wtsi}/Dock2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Dock2^{tm1b(EUCOMM)Wtsi}/BayMmucd	decreased bone mineral density	J:211773
	increased spleen weight	J:211773
Dock2^tm1Tsas/Dock2^tm1Tsas B6.Cg-Dock2^tm1Tsas	abnormal cell migration	J:130919
	abnormal hematopoietic system morphology/development	J:130919
	decreased lymphocyte cell number	J:130919
	decreased mature B cell number	J:130919
	decreased T cell number	J:130919
	impaired neutrophil chemotaxis	J:113266
	increased susceptibility to xenobiotic induced morbidity/mortality	J:130919
Dock2^tm1Tsas/Dock2^tm1Tsas involves: C57BL/6	abnormal immune system morphology	J:71005
	abnormal leukocyte migration	J:71005
	abnormal Peyer's patch morphology	J:71005
	abnormal spleen morphology	J:71005
	abnormal spleen white pulp morphology	J:71005
	decreased marginal zone B cell number	J:71005
	lymph node hypoplasia	J:71005
	spleen hypoplasia	J:71005

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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