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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tmc1
transmembrane channel-like gene family 1
MGI:2151016
27 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tmc1baringo/Tmc1baringo
involves: C57BL/6 		abnormal organ of Corti supporting cell morphology J:181985
abnormal outer hair cell stereociliary bundle morphology J:181985
normal behavior/neurological phenotype J:181985
cochlear degeneration J:181985
cochlear inner hair cell degeneration J:181985
cochlear outer hair cell degeneration J:181985
impaired hearing J:181985
organ of Corti degeneration J:181985
Tmc1dn/Tmc1+
involves: STOCK Grhl3ct * M. m. molossinus 		normal hearing/vestibular/ear phenotype J:22445
Tmc1dn/Tmc1+
STOCK Grhl3ct/J 		normal hearing/vestibular/ear phenotype J:14069
Tmc1dn/Tmc1dn
involves: STOCK Grhl3ct * M. m. molossinus 		abnormal ear morphology J:22445
abnormal hearing physiology J:22445
Tmc1dn/Tmc1dn
STOCK Grhl3ct/J 		abnormal ear morphology J:236, J:1600, J:6409, J:28899, J:32691
abnormal hearing physiology J:236, J:1600, J:6409, J:6806, J:28899, J:32693
abnormal motor capabilities/coordination/movement J:236
abnormal otolith morphology J:236
abnormal scala media morphology J:236
abnormal stria vascularis morphology J:236
abnormal tectorial membrane morphology J:236
cochlear ganglion degeneration J:236
deafness J:236
Deiters cell degeneration J:236
head tossing J:236
normal nervous system phenotype J:6806
organ of Corti degeneration J:236
vestibular saccular macula degeneration J:236
Tmc1Mhdabth/Tmc1+
C3HeB/FeJ-Tmc1Mhdabth/Ieg 		abnormal gait J:86685
deafness J:86685
Tmc1nice/Tmc1nice
involves: C57BL/6 		abnormal Deiters cell morphology J:181985
abnormal outer hair cell stereociliary bundle morphology J:181985
normal behavior/neurological phenotype J:181985
cochlear degeneration J:181985
cochlear inner hair cell degeneration J:181985
cochlear outer hair cell degeneration J:181985
impaired hearing J:181985
Tmc1stitch/Tmc1stitch
involves: BALB/c * C57BL/6 		normal hearing/vestibular/ear phenotype J:181985
impaired hearing J:181985
Tmc1stitch/Tmc1stitch
involves: C57BL/6 		abnormal outer hair cell stereociliary bundle morphology J:181985
normal behavior/neurological phenotype J:181985
cochlear degeneration J:181985
cochlear inner hair cell degeneration J:181985
cochlear outer hair cell degeneration J:181985
impaired hearing J:181985
organ of Corti degeneration J:181985
Tmc1tm1.1Ajg/Tmc1tm1.1Ajg
B6.129-Tmc1tm1.1Ajg 		abnormal hair cell mechanoelectric transduction J:184419
normal behavior/neurological phenotype J:184419
cochlear hair cell degeneration J:184419
cochlear inner hair cell degeneration J:184419
cochlear outer hair cell degeneration J:184419
deafness J:184419
increased or absent threshold for auditory brainstem response J:184419
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory