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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dgcr8
DGCR8, microprocessor complex subunit
MGI:2151114
25 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dgcr8em1Ysa/Dgcr8em1Ysa
Not Specified 		abnormal embryo development J:329565
embryonic lethality J:329565
Dgcr8Gt(XG058)Byg/Dgcr8+
B6.129P2-Dgcr8Gt(XG058)Byg 		abnormal brain interneuron morphology J:201966
abnormal neuronal migration J:201966
decreased dentate gyrus size J:201966
Dgcr8Gt(XG058)Byg/Dgcr8+
involves: 129P2/OlaHsd * C57BL/6 		abnormal nest building behavior J:198659
abnormal neuronal precursor proliferation J:198659
abnormal spatial working memory J:198659
normal behavior/neurological phenotype J:198659
behavioral despair J:198659
impaired spatial learning J:198659
normal nervous system phenotype J:198659
Dgcr8Gt(XG058)Byg/Dgcr8Gt(XG058)Byg
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:198659
Dgcr8Gt(XH157)Byg/Dgcr8+
B6.129P2-Dgcr8Gt(XH157)Byg 		enhanced long-term potentiation J:190908
Dgcr8Gt(XH157)Byg/Dgcr8+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal dendrite morphology J:136969
abnormal spatial working memory J:136969
decreased prepulse inhibition J:136969
normal hearing/vestibular/ear phenotype J:136969
Dgcr8Gt(XH157)Byg/Dgcr8+
Tg(Thy1-EGFP)MJrs/0
involves: 129P2/OlaHsd * C57BL/6J * CBA 		abnormal dendrite morphology J:136969
Dgcr8tm1.1Blel/Dgcr8tm1.1Blel
Tg(Ckmm-cre)5Khn/0
involves: 129S4/SvJae * C57BL/6 * FVB 		abnormal heart ventricle morphology J:161342
cardiac fibrosis J:161342
decreased heart ventricle muscle contractility J:161342
enlarged heart J:161342
premature death J:161342
prolonged PR interval J:161342
prolonged QRS complex duration J:161342
thin ventricular wall J:161342
Dgcr8tm1.2Blel/Dgcr8tm1.2Blel
involves: 129S4/SvJae * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:141670
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory