Selenon Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Selenon
selenoprotein N
MGI:2151208

30 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Selenon^tm1.1Mred/Selenon^tm1.1Mred Tg(ACTA1-cre/ERT2)97.16Mtz/0 involves: 129S2/SvPas * C57BL/6J	no abnormal phenotype detected	J:176499
Selenon^tm1.2Mred/Selenon^tm1.2Mred involves: 129S2/SvPas	abnormal muscle physiology	J:168699
	abnormal muscle regeneration	J:168699
	decreased satellite cell number	J:168699
	skeletal muscle atrophy	J:168699
Selenon^tm1.2Mred/Selenon^tm1.2Mred involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	abnormal muscle physiology	J:176499
	abnormal skeletal muscle fiber type ratio	J:176499
	abnormal skeletal muscle morphology	J:176499
	centrally nucleated skeletal muscle fibers	J:176499
	decreased extensor digitorum longus weight	J:176499
	decreased gastrocnemius weight	J:176499
	decreased quadriceps weight	J:176499
	decreased skeletal muscle fiber diameter	J:176499
	decreased skeletal muscle fiber size	J:176499
	decreased skeletal muscle mass	J:176499
	decreased soleus weight	J:176499
	decreased susceptibility to weight gain	J:176499
	decreased tibialis anterior weight	J:176499
	kyphosis	J:176499
	skeletal muscle atrophy	J:176499
Selenon^{tm1a(KOMP)Wtsi}/Selenon^{tm1a(KOMP)Wtsi} B6JTyr;B6N-Selenon^{tm1a(KOMP)Wtsi}/Wtsi	vertebral fusion	J:175295
Selenon^tm1Begg/Selenon^tm1Begg involves: C57BL/6 * C57BL/6NTac	abnormal lung development	J:197753
	abnormal lung volume	J:197753
	abnormal pulmonary alveolar sac morphology	J:197753
	abnormal respiratory system physiology	J:197753
	abnormal skeletal muscle morphology	J:197753
	decreased locomotor activity	J:197753
	decreased lung elastance	J:197753
	decreased vertical activity	J:197753
	enhanced exercise endurance	J:197753
	increased apoptosis	J:197753
	increased lung compliance	J:197753
	skeletal muscle hypertrophy	J:197753

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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