Dph1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dph1
diphthamide biosynthesis 1
MGI:2151233

50 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dph1^em1Swei/Dph1^em2Swei C57BL/6J-Dph1^em1Swei Dph1^em2Swei	decreased embryo size	J:347602
	palatal shelves fail to meet at midline	J:347602
	prenatal lethality, complete penetrance	J:347602
	short Meckel's cartilage	J:347602
	small mandible	J:347602
Dph1^tm1.1Cmch/Dph1^tm1.1Cmch Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA	abnormal tongue position	J:214744
	absent palatine bone	J:214744
	cleft palate	J:214744
	edema	J:214744
	fetal growth retardation	J:214744
	mandible hypoplasia	J:214744
	neonatal lethality, complete penetrance	J:214744
	palatal shelves fail to meet at midline	J:214744
	pallor	J:214744
	short mandible	J:214744
	small cranium	J:214744
Dph1^tm1.1Cmch/Dph1^tm1.1Cmch H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	cleft palate	J:214744
	decreased cranium length	J:214744
	postnatal lethality, incomplete penetrance	J:214744
	round face	J:214744
	short mandible	J:214744
	short Meckel's cartilage	J:214744
	short nasal bone	J:214744
Dph1^tm1.1Cmch/Dph1^tm1.1Cmch Mesp1^tm2(cre)Ysa/Mesp1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	normal craniofacial phenotype	J:214744
	postnatal lethality, incomplete penetrance	J:214744
Dph1^tm1Bhr/Dph1⁺ involves: 129/Sv * C57BL/6	increased tumor incidence	J:88090
Dph1^tm1Bhr/Dph1^tm1Bhr either: 129/Sv or (involves: 129/Sv * C57BL/6)	abnormal cell cycle	J:88090
	abnormal craniofacial bone morphology	J:88090
	abnormal lung development	J:88090
	abnormal neural tube morphology	J:88090
	abnormal skeleton development	J:88090
	cleft palate	J:88090
	decreased fetal weight	J:88090
	embryonic growth retardation	J:88090
	embryonic lethality during organogenesis, incomplete penetrance	J:88090
	embryonic lethality, complete penetrance	J:88090
	hydrops fetalis	J:88090
	increased nucleated erythrocyte cell number	J:88090
	neonatal lethality, complete penetrance	J:88090
	preaxial polydactyly	J:88090
	primary atelectasis	J:88090
	respiratory failure	J:88090
	thick lung-associated mesenchyme	J:88090
Dph1^tm1Bhr/Dph1^tm1Bhr involves: 129S4/SvJae	abnormal cell physiology	J:188600
	decreased fibroblast proliferation	J:188600
	decreased sensitivity to induced cell death	J:188600
Dph1^tm1Bhr/Dph1^tm2Bhr involves: 129/Sv * C57BL/6	decreased fetal weight	J:88090
	embryonic growth retardation	J:88090
	embryonic lethality during organogenesis, incomplete penetrance	J:88090
	hydrops fetalis	J:88090
	neonatal lethality, complete penetrance	J:88090
Dph1^tm2Bhr/Dph1⁺ involves: 129/Sv * C57BL/6	increased tumor incidence	J:88090
Dph1^tm2Bhr/Dph1^tm2Bhr either: 129/Sv or (involves: 129/Sv * C57BL/6)	abnormal cell cycle	J:88090
	abnormal craniofacial bone morphology	J:88090
	abnormal embryo turning	J:88090
	abnormal eye morphology	J:88090
	abnormal eye pigmentation	J:88090
	abnormal hepatoblast morphology	J:88090
	abnormal lung development	J:88090
	abnormal neural tube morphology	J:88090
	abnormal skeleton development	J:88090
	abnormal somite development	J:88090
	cleft palate	J:88090
	decreased fetal weight	J:88090
	embryonic growth retardation	J:88090
	embryonic lethality during organogenesis, incomplete penetrance	J:88090
	embryonic lethality, complete penetrance	J:88090
	hydrops fetalis	J:88090
	increased nucleated erythrocyte cell number	J:88090
	liver degeneration	J:88090
	neonatal lethality, complete penetrance	J:88090
	preaxial polydactyly	J:88090
	primary atelectasis	J:88090
	respiratory failure	J:88090
	thick lung-associated mesenchyme	J:88090
Dph1^tm2Bhr/Dph1^tm2Bhr involves: 129S4/SvJae * C57BL/6J	abnormal tongue position	J:214744
	absent palatine bone	J:214744
	cleft secondary palate	J:214744
	decreased body size	J:214744
	decreased palatal shelf size	J:214744
	lethality at weaning, complete penetrance	J:214744
	micrognathia	J:214744
	palatal shelves fail to meet at midline	J:214744
	preaxial polydactyly	J:214744
	short Meckel's cartilage	J:214744
	small cranium	J:214744

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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