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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
MGI:2152213
13 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tirapm1Btlr/Tirapm1Btlr
C57BL/6J-Tirapm1Btlr 		abnormal interferon secretion J:133618
decreased tumor necrosis factor secretion J:133618
Tiraptm1Aki/Tiraptm1Aki
B6.129P2-Tiraptm1Aki 		abnormal dendritic cell physiology J:118954
decreased interleukin-6 secretion J:118954
decreased interleukin-12b secretion J:118954
Tiraptm1Aki/Tiraptm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal cytokine secretion J:111205
abnormal level of surface class II molecules J:111205
decreased IgG3 level J:137066
Tiraptm1Medz/Tiraptm1Medz
involves: 129S1/Sv 		abnormal macrophage physiology J:96018
abnormal response to cardiac infarction J:119941
increased susceptibility to bacterial infection J:96018
increased susceptibility to induced morbidity/mortality J:96018
Tiraptm1Medz/Tiraptm1Medz
involves: 129S1/Sv * C57BL/6 		abnormal dendritic cell physiology J:96773
abnormal macrophage physiology J:96773
decreased B cell proliferation J:96773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory