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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gsk3a
glycogen synthase kinase 3 alpha
MGI:2152453
29 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gsk3atm1.1Jrw/Gsk3atm1.1Jrw
involves: 129S6/SvEvTac * C57BL/6 		decreased percent body fat/body weight J:130033
improved glucose tolerance J:130033
increased insulin sensitivity J:130033
increased lean body mass J:130033
increased liver glycogen level J:130033
Gsk3atm1.2Svij/Gsk3a+
involves: 129S4/SvJaeSor * C57BL/6 		abnormal sperm head morphology J:221688
abnormal sperm midpiece morphology J:221688
normal reproductive system phenotype J:221688
Gsk3atm1.2Svij/Gsk3atm1.2Svij
involves: 129S4/SvJaeSor * C57BL/6 		abnormal sperm head morphology J:221688
abnormal sperm midpiece morphology J:221688
asthenozoospermia J:221688
male infertility J:221688
oligozoospermia J:221688
Gsk3atm1a(EUCOMM)Hmgu/Gsk3a+
Not Specified 		abnormal gait J:165965
hyperactivity J:165965
Gsk3atm1a(EUCOMM)Hmgu/Gsk3atm1a(EUCOMM)Hmgu
Not Specified 		abnormal gait J:165965
Gsk3atm1a(EUCOMM)Wtsi/Gsk3atm1a(EUCOMM)Wtsi
B6JTyr;B6N-Gsk3atm1a(EUCOMM)Wtsi/Wtsi 		decreased body length J:175295
decreased body weight J:175295
decreased circulating glucose level J:175295
decreased circulating glycerol level J:175295
decreased lumbar vertebrae number J:175295
decreased total body fat amount J:175295
increased sacral vertebrae number J:175295
Gsk3atm1a(EUCOMM)Wtsi/Gsk3atm1a(EUCOMM)Wtsi
involves: C57BL/6N 		normal craniofacial phenotype J:195008
wide metopic suture J:195008
Gsk3atm1b(EUCOMM)Hmgu/Gsk3atm1b(EUCOMM)Hmgu
C57BL/6N-Gsk3atm1b(EUCOMM)Hmgu/Ieg 		decreased exploration in new environment J:211773
decreased mean platelet volume J:211773
decreased startle reflex J:211773
improved glucose tolerance J:211773
increased circulating alkaline phosphatase level J:211773
increased lean body mass J:211773
prolonged QRS complex duration J:211773
Gsk3atm1Dral/Gsk3atm1Dral
involves: 129P2/OlaHsd * C57BL/6 		normal homeostasis/metabolism phenotype J:98263
no abnormal phenotype detected J:98263
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory