Fbxl5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fbxl5
F-box and leucine-rich repeat protein 5
MGI:2152883

39 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fbxl5^{Gt(OST386421)Lex}/Fbxl5⁺ 129S(B6)-Fbxl5^{Gt(OST386421)Lex}	abnormal erythrocyte morphology	J:193752
Fbxl5^{Gt(OST386421)Lex}/Fbxl5⁺ involves: 129S5/SvEvBrd * C57BL/6	abnormal erythrocyte morphology	J:193752
	abnormal iron homeostasis	J:193752
	decreased liver iron level	J:193752
	increased intestinal iron level	J:193752
	increased spleen iron level	J:193752
Fbxl5^{Gt(OST386421)Lex}/Fbxl5^{Gt(OST386421)Lex} involves: 129S5/SvEvBrd * C57BL/6	embryonic growth retardation	J:193752
	embryonic lethality during organogenesis, complete penetrance	J:193752
Fbxl5^L5Jcs32/Fbxl5^L5Jcs32 involves: C3HeB/FeJ * C57BL/6J	embryonic lethality, complete penetrance	J:100332
	open neural tube	J:100332
	pericardial edema	J:100332
Fbxl5^tm1Kei/Fbxl5^tm1Kei B6.129-Fbxl5^tm1Kei	abnormal ectoplacental cone morphology	J:176655
	abnormal embryo development	J:176655
	abnormal extraembryonic tissue physiology	J:176655
	abnormal iron level	J:176655
	embryonic growth retardation	J:176655
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:176655
	hemorrhage	J:176655
	increased embryonic tissue cell apoptosis	J:176655
	internal hemorrhage	J:176655
	oxidative stress	J:176655
Fbxl5^tm2.1Kei/Fbxl5^tm2.1Kei involves: C57BL/6	abnormal iron level	J:176655
	abnormal mitochondrial physiology	J:176655
	oxidative stress	J:176655
Fbxl5^tm2.1Kei/Fbxl5^tm2.1Kei Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * DBA	abnormal blood coagulation	J:176655
	abnormal circulating enzyme level	J:176655
	abnormal hepatocyte mitochondrial morphology	J:176655
	abnormal hepatocyte morphology	J:176655
	abnormal liver physiology	J:176655
	decreased circulating unsaturated transferrin level	J:176655
	hepatic steatosis	J:176655
	increased circulating alanine transaminase level	J:176655
	increased circulating aspartate transaminase level	J:176655
	increased circulating iron level	J:176655
	increased circulating lactate dehydrogenase level	J:176655
	increased liver iron level	J:176655
	increased partial thromboplastin time	J:176655
	increased prothrombin time	J:176655
	increased susceptibility to induced morbidity/mortality	J:176655
	liver failure	J:176655
	liver hemorrhage	J:176655
	liver inflammation	J:176655
	pale liver	J:176655

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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