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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Srgap3
SLIT-ROBO Rho GTPase activating protein 3
MGI:2152938
21 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Srgap3tm1.1Ssod/Srgap3+
Tg(Thy1-EGFP)OJrs/0
involves: C57BL/6J * CBA 		abnormal dendritic spine morphology J:169533
Srgap3tm1.1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-EGFP)OJrs/0
involves: C57BL/6J * CBA 		abnormal dendritic spine morphology J:169533
Srgap3tm1.1Zi/Srgap3tm1.1Zi
B6.129(SJL)-Srgap3tm1.1Zi 		abnormal brain white matter morphology J:192388
abnormal dendritic spine morphology J:192388
abnormal motor capabilities/coordination/movement J:192388
abnormal response to novel object J:192388
abnormal social investigation J:192388
abnormal spatial working memory J:192388
normal behavior/neurological phenotype J:192388
cerebral edema J:192388
decreased circulating testosterone level J:192388
decreased locomotor activity J:192388
decreased prepulse inhibition J:192388
enlarged brain ventricles J:192388
hydrocephaly J:192388
induced hyperactivity J:192388
premature death J:192388
Srgap3tm1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
involves: C57BL/6 * SJL 		normal nervous system phenotype J:169533
Srgap3tm1Ssod/Srgap3tm1Ssod
Not Specified 		abnormal dendritic spine morphology J:169533
abnormal neuron morphology J:169533
Srgap3tm1Ssod/Srgap3tm1Ssod
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal learning/memory/conditioning J:169533
abnormal long-term spatial reference memory J:169533
impaired long-term object recognition memory J:169533
impaired passive avoidance behavior J:169533
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory