Sp7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sp7
Sp7 transcription factor 7
MGI:2153568

18 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sox9^tm3(cre)Crm/Sox9⁺ Sp7^tm1Crm/Sp7^tm2Crm involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal axial skeleton morphology	J:102495
	abnormal bone mineralization	J:102495
	abnormal bone ossification	J:102495
	abnormal limb bone morphology	J:102495
	abnormal osteoblast differentiation	J:102495
	abnormal rib morphology	J:102495
	abnormal skeleton development	J:102495
	abnormal trabecular bone morphology	J:102495
	abnormal vertebrae morphology	J:102495
	neonatal lethality, complete penetrance	J:102495
Sp7^tm1.1Amc/Sp7^tm1.1Amc involves: 129S4/SvJae * C57BL/6 * CBA	no abnormal phenotype detected	J:235520
Sp7^tm1.1Rnis/Sp7^tm1.1Rnis involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	abnormal skeleton development	J:191589
	failure of bone ossification	J:191589
	failure of endochondral bone ossification	J:191589
Sp7^tm1Crm/Sp7^tm1Crm involves: 129S7/SvEvBrd * C57BL/6	abnormal axial skeleton morphology	J:74344
	abnormal bone mineralization	J:74344
	abnormal limb morphology	J:74344
	abnormal rib morphology	J:74344
	abnormal vertebrae morphology	J:74344
	clavicle hypoplasia	J:74344
	cyanosis	J:74344
	neonatal lethality, complete penetrance	J:74344
	respiratory distress	J:74344
Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col2a1-cre)1Bhr/0 involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL	abnormal skeleton development	J:191589
	failure of endochondral bone ossification	J:191589
	rickets	J:191589
Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col11a2-cre)1Ntsu/0 involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA/2	failure of endochondral bone ossification	J:191589
Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Prrx1-cre)1Cjt/0 involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J	failure of endochondral bone ossification	J:191589

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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