Ripk3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ripk3
receptor-interacting serine-threonine kinase 3
MGI:2154952

21 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Ripk3^tm1Arte/Ripk3^tm1Arte involves: C57BL/6NTac	abnormal crypts of Lieberkuhn morphology	J:209137
	abnormal intestine physiology	J:209137
	abnormal lymphocyte morphology	J:209137
	blunted small intestinal villi	J:209137
	diarrhea	J:209137
	fused small intestinal villi	J:209137
	intestinal edema	J:209137
	intestinal inflammation	J:209137
	normal mortality/aging	J:209137
	thymus atrophy	J:209137
	weight loss	J:209137
Ripk3^m1Btlr/Ripk3^m1Btlr C57BL/6J-Ripk3^m1Btlr	no abnormal phenotype detected	J:101977
Ripk3^{tm1.1(KOMP)Wtsi}/Ripk3^{tm1.1(KOMP)Wtsi} C57BL/6N-Ripk3^{tm1.1(KOMP)Wtsi}/Ucd	abnormal kidney morphology	J:211773
	absent vibrissae	J:211773
Ripk3^tm1Vmd/Ripk3^tm1Vmd B6.129-Ripk3^tm1Vmd	decreased inflammatory response	J:179279
Ripk3^tm1Vmd/Ripk3^tm1Vmd B6.129-Ripk3^tm1Vmd	decreased susceptibility to induced morbidity/mortality	J:179279
Ripk3^tm1Vmd/Ripk3^tm1Vmd involves: 129S1/Sv * 129X1/SvJ	normal mortality/aging	J:204622
Ripk3^tm1Vmd/Ripk3^tm1Vmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	normal immune system phenotype	J:87683
Ripk3^tm1Xidw/Ripk3^tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased sensitivity to induced cell death	J:157346
	decreased susceptibility to induced pancreatitis	J:157346
Ripk3^tm1Xidw/Ripk3^tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl	decreased susceptibility to induced morbidity/mortality	J:298682
Ripk3^tm2Vmd/Ripk3^tm2Vmd involves: C57BL/6N	abnormal vitelline vasculature morphology	J:209137
Ripk3^tm2Vmd/Ripk3^tm2Vmd involves: C57BL/6N	embryonic lethality prior to tooth bud stage	J:209137

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24