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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sec63
SEC63 homolog, protein translocation regulator
MGI:2155302
16 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sec63tm1.1Som/Sec63tm1.1Som
involves: 129 * C57BL/6 		embryonic lethality, complete penetrance J:188763
Sec63tm1b(EUCOMM)Hmgu/Sec63+
C57BL/6N-Sec63tm1b(EUCOMM)Hmgu/Bay 		abnormal vibrissa morphology J:211773
absent vibrissae J:211773
decreased bone mineral density J:211773
decreased lymphocyte cell number J:211773
increased circulating alanine transaminase level J:211773
increased neutrophil cell number J:211773
Sec63tm1b(EUCOMM)Hmgu/Sec63tm1b(EUCOMM)Hmgu
C57BL/6N-Sec63tm1b(EUCOMM)Hmgu/Bay 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 		liver cyst J:188763
premature death J:188763
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * ICR 		abnormal loop of Henle ascending limb thick segment morphology J:188763
dilated kidney collecting duct J:188763
increased blood urea nitrogen level J:188763
kidney cyst J:188763
premature death J:188763
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory