Ttbk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ttbk2
tau tubulin kinase 2
MGI:2155779

24 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ttbk2^bby/Ttbk2^bby involves: C57BL/6J * FVB	abnormal cilium morphology	J:197579
	abnormal direction of heart looping	J:197579
	abnormal embryonic tissue morphology	J:197579
	abnormal limb development	J:197579
	abnormal neural tube morphology	J:197579
	embryonic lethality during organogenesis, complete penetrance	J:197579
	holoprosencephaly	J:197579
Ttbk2^bby/Ttbk2^{tm1a(EUCOMM)Hmgu} involves: C57BL/6 * C57BL/6N	abnormal cilium morphology	J:269515
	abnormal nervous system development	J:269515
	perinatal lethality, complete penetrance	J:269515
	polydactyly	J:269515
Ttbk2^bby/Ttbk2^tm1Dral involves: C57BL/6	absent embryonic cilia	J:269515
Ttbk2^em1(IMPC)J/Ttbk2^em1(IMPC)J C57BL/6NJ-Ttbk2^em1(IMPC)J/Mmjax	embryonic lethality prior to tooth bud stage	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Ttbk2^{tm1a(EUCOMM)Hmgu}/Ttbk2^{tm1a(EUCOMM)Hmgu} involves: C57BL/6 * C57BL/6N	abnormal cilium morphology	J:269515
	hydrocephaly	J:269515
	polycystic kidney	J:269515
Ttbk2^tm1Dral/Ttbk2⁺ involves: C57BL/6	normal nervous system phenotype	J:269515
Ttbk2^tm1Dral/Ttbk2^{tm1a(EUCOMM)Hmgu} involves: C57BL/6 * C57BL/6N	abnormal cilium morphology	J:269515
	abnormal nervous system development	J:269515
	abnormal neural tube morphology	J:269515
	polydactyly	J:269515
	prenatal lethality, incomplete penetrance	J:269515
Ttbk2^tm1Dral/Ttbk2^tm1Dral involves: C57BL/6	abnormal brain development	J:173629
	abnormal cell physiology	J:269515
	abnormal cranial flexure morphology	J:269515
	abnormal direction of heart looping	J:269515
	abnormal nervous system development	J:269515
	absent embryonic cilia	J:269515
	decreased embryo size	J:173629
	embryonic growth retardation	J:173629
	holoprosencephaly	J:269515
	incomplete embryo turning	J:173629
	preweaning lethality, complete penetrance	J:173629

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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