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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rrm2b
ribonucleotide reductase M2 B (TP53 inducible)
MGI:2155865
66 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rrm2bem1Mem/Rrm2bem1Mem
C57BL/6J-Rrm2bem1Mem 		pale kidney J:298297
premature death J:298297
weight loss J:298297
Rrm2bem2Mem/Rrm2bem2Mem
C57BL/6J-Rrm2bem2Mem 		pale kidney J:298297
premature death J:298297
weight loss J:298297
Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal blood homeostasis J:186071
abnormal compact bone morphology J:186071
abnormal glomerular capillary endothelium morphology J:186071
abnormal glomerular capillary morphology J:186071
abnormal glomerular capsule parietal layer morphology J:186071
abnormal glomerular endothelium fenestra morphology J:186071
abnormal glomerular mesangium morphology J:186071
abnormal podocyte morphology J:186071
abnormal renal glomerular capsule morphology J:186071
abnormal renal glomerulus basement membrane morphology J:186071
abnormal renal glomerulus morphology J:186071
abnormal renal tubule epithelium morphology J:186071
abnormal renal tubule morphology J:186071
abnormal urine homeostasis J:186071
cortical renal glomerulopathies J:186071
decreased circulating alkaline phosphatase level J:186071
decreased circulating glucose level J:186071
decreased circulating serum albumin level J:186071
decreased glomerular capillary number J:186071
decreased hematocrit J:186071
decreased hemoglobin content J:186071
decreased lean body mass J:186071
decreased total body fat amount J:186071
dilated renal tubule J:186071
enlarged kidney J:186071
hyperlipidemia J:186071
increased blood urea nitrogen level J:186071
increased circulating cholesterol level J:186071
increased circulating creatinine level J:186071
increased circulating phosphate level J:186071
increased circulating triglyceride level J:186071
increased glomerular capsule space J:186071
increased kidney apoptosis J:186071
increased kidney cell proliferation J:186071
increased renal glomerulus basement membrane thickness J:186071
increased renal tubule apoptosis J:186071
increased urine protein level J:186071
kidney failure J:186071
normal liver/biliary system phenotype J:186071
muscular atrophy J:186071
pale kidney J:186071
podocyte foot process effacement J:186071
podocyte hypertrophy J:186071
premature death J:186071
proximal convoluted tubule brush border loss J:186071
renal glomerulus fibrosis J:186071
renal tubular necrosis J:186071
renal tubule atrophy J:186071
normal renal/urinary system phenotype J:186071
slow postnatal weight gain J:186071
spleen atrophy J:186071
thrombocytosis J:186071
thymus atrophy J:186071
Rrm2btm1Ynak/Rrm2btm1Ynak
involves: 129 * C57BL/6J 		abnormal coronary artery morphology J:84841
abnormal kidney physiology J:84841
abnormal liver morphology J:84841
abnormal mesenteric lymph node morphology J:84841
abnormal sciatic nerve morphology J:84841
abnormal submandibular gland morphology J:84841
cardiac fibrosis J:84841
decreased circulating serum albumin level J:84841
decreased spleen white pulp amount J:84841
dilated renal tubule J:84841
glomerulosclerosis J:84841
increased blood urea nitrogen level J:84841
increased circulating creatinine level J:84841
increased kidney apoptosis J:84841
increased urine protein level J:84841
kidney failure J:84841
postnatal growth retardation J:84841
premature death J:84841
skeletal muscle atrophy J:84841
thymus cortex hypoplasia J:84841
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory