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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nphs2
nephrosis 2, podocin
MGI:2157018
54 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nphs2tm1Antc/Nphs2tm1Antc
129-Nphs2tm1Antc 		abnormal podocyte foot process morphology J:87577
abnormal podocyte morphology J:87577
abnormal renal glomerulus morphology J:87577
absent podocyte slit diaphragm J:87577
albuminuria J:87577
cortical renal glomerulopathies J:87577
decreased body size J:87577
dilated proximal convoluted tubule J:87577
expanded mesangial matrix J:87577
glomerular crescent J:87577
increased blood urea nitrogen level J:87577
increased circulating creatinine level J:87577
increased urine protein level J:87577
kidney failure J:87577
podocyte foot process effacement J:87577
postnatal lethality, complete penetrance J:87577
normal renal/urinary system phenotype J:87577
Nphs2tm1Antc/Nphs2tm1Antc
involves: 129 * C57BL/6J 		abnormal glomerular capillary endothelium morphology J:87577
abnormal glomerular capillary morphology J:87577
abnormal kidney arterial blood vessel morphology J:87577
abnormal kidney cortex morphology J:87577
abnormal peritubular capillary morphology J:87577
abnormal podocyte foot process morphology J:87577
abnormal podocyte morphology J:87577
abnormal renal glomerular capsule morphology J:87577
abnormal renal glomerulus basement membrane morphology J:87577
abnormal renal glomerulus morphology J:87577
abnormal renal tubule epithelium morphology J:87577
absent podocyte slit diaphragm J:87577
albuminuria J:87577
cortical renal glomerulopathies J:87577
decreased body size J:87577
dilated proximal convoluted tubule J:87577
expanded mesangial matrix J:87577
increased blood urea nitrogen level J:87577
increased circulating creatinine level J:87577
increased urine protein level J:87577
kidney failure J:87577
kidney hemorrhage J:87577
mesangiolysis J:87577
podocyte foot process effacement J:87577
podocyte hypertrophy J:87577
podocyte microvillus transformation J:87577
postnatal lethality, complete penetrance J:87577
renal cast J:87577
renal glomerulus hypertrophy J:87577
Nphs2tm1Antc/Nphs2tm3.1Antc
Tg(CAG-cre/Esr1*)86Lbgn/0
involves: 129 * C57BL/6 * DBA 		abnormal kidney morphology J:166320
abnormal renal glomerulus morphology J:166320
abnormal renal tubule morphology J:166320
albuminuria J:166320
dilated renal tubule J:166320
expanded mesangial matrix J:166320
glomerulosclerosis J:166320
increased blood urea nitrogen level J:166320
increased circulating cholesterol level J:166320
increased circulating creatinine level J:166320
increased mesangial cell number J:166320
increased systemic arterial systolic blood pressure J:166320
increased urine protein level J:166320
podocyte foot process effacement J:166320
podocyte hypertrophy J:166320
premature death J:166320
renal cast J:166320
renal interstitial fibrosis J:166320
renal tubular necrosis J:166320
renal tubule atrophy J:166320
Nphs2tm2.1Antc/Nphs2tm2.1Antc
involves: 129S2/SvPas * C57BL/6 		abnormal glomerular capillary endothelium morphology J:152878
abnormal glomerular capillary morphology J:152878
abnormal glomerular endothelium fenestra morphology J:152878
abnormal podocyte morphology J:152878
abnormal proximal convoluted tubule morphology J:152878
abnormal renal tubule morphology J:152878
absent podocyte slit diaphragm J:152878
albuminuria J:152878
dilated glomerular capillary J:152878
dilated proximal convoluted tubule J:152878
dilated renal tubule J:152878
expanded mesangial matrix J:152878
glomerulosclerosis J:152878
increased blood urea nitrogen level J:152878
increased circulating creatinine level J:152878
kidney hemorrhage J:152878
mesangiolysis J:152878
perinatal lethality, incomplete penetrance J:152878
podocyte foot process effacement J:152878
postnatal lethality, complete penetrance J:152878
renal cast J:152878
Nphs2tm2.1Antc/Nphs2tm3.1Antc
Tg(CAG-cre/Esr1*)86Lbgn/0
involves: 129S2/SvPas * C57BL/6 * DBA 		abnormal podocyte foot process morphology J:245693
decreased body weight J:245693
decreased circulating serum albumin level J:245693
decreased creatinine clearance J:245693
decreased podocyte number J:245693
fused podocyte foot processes J:245693
glomerulosclerosis J:245693
increased circulating cholesterol level J:245693
increased renal glomerulus basement membrane thickness J:245693
increased systemic arterial blood pressure J:245693
increased urine creatinine level J:245693
increased urine protein level J:245693
kidney failure J:245693
podocyte foot process effacement J:245693
premature death J:245693
renal interstitial fibrosis J:245693
renal tubule atrophy J:245693
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory