Khdrbs2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
MGI:2159649

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd Khdrbs2^tm1.1Schei/Khdrbs2^tm1.1Schei involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ	decreased brain size	J:208331
	delaminated Purkinje cell layer	J:208331
	infertility	J:208331
	reduced cerebellar foliation	J:208331
	small cerebellum	J:208331
Khdrbs2^{Tg(LRRK2R1441G)135Cjli}/Khdrbs2⁺ FVB-Khdrbs2^{Tg(LRRK2R1441G)135Cjli}	abnormal axon morphology	J:149135
	abnormal dopaminergic neuron morphology	J:149135
	abnormal locomotor activation	J:149135
	akinesia	J:149135
	decreased dopamine level	J:149135
	decreased locomotor activity	J:149135
	normal nervous system phenotype	J:149135
	tau protein deposits	J:149135
Khdrbs2^{Tg(LRRK2R1441G)135Cjli}/Khdrbs2⁺ FVB/N-Khdrbs2^{Tg(LRRK2R1441G)135Cjli}/J	abnormal autophagy	J:194153
	abnormal digestive system physiology	J:204940
	abnormal locomotor activation	J:204940
	alpha-synuclein inclusion body	J:194153
	normal behavior/neurological phenotype	J:204940
	constipation	J:204940
	decreased locomotor activity	J:204940
	decreased vertical activity	J:204940
	diarrhea	J:204940

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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