Cyp26b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
MGI:2176159

47 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp26b1^em1Oncl/Cyp26b1^em1Oncl involves: C57BL/6J	abnormal aortic valve cusp morphology	J:325730
	abnormal semilunar valve morphology	J:325730
	abnormal vitamin A metabolism	J:325730
	enlarged aortic valve	J:325730
	heart valve hyperplasia	J:325730
	thick aortic valve cusps	J:325730
	ventricular septal defect	J:325730
Cyp26b1^tm1.1Ptk/Cyp26b1^tm1.1Ptk involves: 129S2/SvPas	abnormal craniofacial morphology	J:126705
	abnormal limb morphology	J:126705
	abnormal male germ cell apoptosis	J:126705
	decreased male germ cell number	J:126705
	neonatal lethality, complete penetrance	J:126705
	respiratory distress	J:126705
	small testis	J:126705
Cyp26b1^tm1Dcp/Cyp26b1^tm1Dcp involves: 129S4/SvJae * C57BL/6	abnormal embryo development	J:215225
	abnormal embryonic tissue morphology	J:215225
	abnormal male meiosis	J:215225
	perinatal lethality, complete penetrance	J:215225
Cyp26b1^tm1Hmd/Cyp26b1^tm1Hmd involves: 129S1/Sv * 129X1/SvJ	abnormal corneocyte envelope morphology	J:192725
	abnormal epidermal layer morphology	J:192725
	abnormal epidermis stratum basale morphology	J:192725
	abnormal epidermis stratum corneum morphology	J:192725
	abnormal hair follicle development	J:192725
	abnormal lymphatic vessel endothelial cell morphology	J:206581
	absent keratohyalin granules	J:192725
	impaired skin barrier function	J:192725
Cyp26b1^tm1Hmd/Cyp26b1^tm1Hmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal apoptosis	J:89029
	abnormal forelimb morphology	J:89029
	abnormal hindlimb morphology	J:89029
	abnormal limb bone morphology	J:89029
	abnormal limb morphology	J:89029
	abnormal proximal-distal axis patterning	J:89029
	delayed chondrocyte differentiation	J:89029
	eyelids open at birth	J:89029
	micrognathia	J:89029
	neonatal lethality, complete penetrance	J:89029
	oligodactyly	J:89029
	respiratory distress	J:89029
	short forelimb	J:89029
	short hindlimb	J:89029
Cyp26b1^tm1Hmd/Cyp26b1^tm1Hmd Tg(Prox1-EGFP)KY221Gsat/0 involves: 129S1/Sv * 129X1/SvJ * FVB/NTac	abnormal lymphatic vessel endothelial cell morphology	J:206581
	abnormal lymphatic vessel morphology	J:206581
	normal cardiovascular system phenotype	J:206581
	hemorrhage	J:206581
	skin edema	J:206581
Cyp26b1^tm1Ptk/Cyp26b1^tm1Ptk Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ involves: 129S2/SvPas * C57BL/6 * SJL	abnormal male meiosis	J:154048
	abnormal seminiferous tubule morphology	J:154048
	abnormal spermatogenesis	J:154048
	decreased male germ cell number	J:154048
	increased Leydig cell number	J:154048
	small seminiferous tubules	J:154048
	small testis	J:154048
Cyp26b1^tm2Hmd/Cyp26b1^tm1Hmd Tg(Hoxb6-cre)#Mku/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCr	abnormal limb development	J:192725
	normal integument phenotype	J:192725

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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