Fktn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fktn
fukutin
MGI:2179507

35 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fktn^tm1.2Kcam/Fktn^tm1.2Kcam involves: 129S/SvEv	embryonic lethality, complete penetrance	J:187144
Fktn^tm1Kcam/Fktn^tm1Kcam involves: 129S/SvEv	embryonic lethality, incomplete penetrance	J:187144
Fktn^tm1Kcam/Fktn^tm1Kcam Myf5^tm3(cre)Sor/Myf5⁺ involves: 129S/SvEv * 129S4/SvJaeSor	decreased body weight	J:187144
	decreased grip strength	J:187144
	dystrophic muscle	J:187144
	increased circulating creatine kinase level	J:187144
	premature death	J:187144
Fktn^tm1Kcam/Fktn^tm1Kcam Tg(CAG-cre/Esr1)5Amc/? involves: 129S/SvEv C57BL/6 * CBA	normal behavior/neurological phenotype	J:187144
	dystrophic muscle	J:187144
	normal growth/size/body region phenotype	J:187144
	increased circulating creatine kinase level	J:187144
Fktn^tm1Kcam/Fktn^tm1Kcam Tg(Ckmm-cre)5Khn/? involves: 129S/SvEv * FVB	dystrophic muscle	J:187144
	increased circulating creatine kinase level	J:187144
	weakness	J:187144
Fktn^tm1Ttd/Fktn^tm1Ttd involves: 129S7/SvEvBrd * C57BL/6	abnormal developmental patterning	J:97950
	abnormal egg cylinder morphology	J:97950
	abnormal Reichert's membrane morphology	J:97950
	abnormal Reichert's membrane thickness	J:97950
	abnormal visceral yolk sac cavity morphology	J:97950
	absent Reichert's membrane	J:97950
	decreased embryo size	J:97950
	embryonic growth arrest	J:97950
	embryonic lethality between implantation and placentation, incomplete penetrance	J:97950
	embryonic lethality during organogenesis, complete penetrance	J:97950
	impaired basement membrane formation	J:97950
	increased embryonic epiblast cell apoptosis	J:97950
Fktn^tm3.1Ttd/Fktn^tm3.1Ttd Myf5^tm3(cre)Sor/Myf5⁺ involves: 129S4/SvJaeSor * C57BL/6	abnormal muscle precursor cell morphology	J:198535
	abnormal muscle precursor cell physiology	J:198535
	centrally nucleated skeletal muscle fibers	J:198535
	decreased body weight	J:198535
	decreased satellite cell number	J:198535
	decreased skeletal muscle weight	J:198535
	impaired skeletal muscle regeneration	J:198535
	increased circulating creatine kinase level	J:198535
	increased collagen deposition in the muscles	J:198535
	increased variability of skeletal muscle fiber size	J:198535
	postnatal growth retardation	J:198535
	premature death	J:198535
	skeletal muscle atrophy	J:198535
	skeletal muscle fibrosis	J:198535
	skeletal muscle necrosis	J:198535
Fktn^tm3.1Ttd/Fktn^tm3.1Ttd Tg(Ckmm-cre)5Khn/0 involves: C57BL/6 * FVB	abnormal skeletal muscle fiber morphology	J:198535
	centrally nucleated skeletal muscle fibers	J:198535
	dystrophic muscle	J:198535
	increased circulating creatine kinase level	J:198535
	skeletal muscle necrosis	J:198535

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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