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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
MGI:2180140
28 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Csf1r-Tnfsf15,-EGFP)#Targ/0
involves: C57BL/6 		abnormal ileum morphology J:169462
abnormal intestinal goblet cell morphology J:169462
abnormal joint morphology J:169462
blunted small intestinal villi J:169462
hemarthrosis J:169462
increased interferon-gamma secretion J:169462
increased Paneth cell number J:169462
intestinal fibrosis J:169462
joint swelling J:169462
skin lesions J:169462
small intestinal inflammation J:169462
Tg(Lck-Tnfsf15,-EGFP)#Targ/0
involves: C57BL/6 		abnormal ileum morphology J:169462
abnormal intestinal goblet cell morphology J:169462
abnormal joint morphology J:169462
blunted small intestinal villi J:169462
hemarthrosis J:169462
increased CD4-positive, alpha-beta memory T cell number J:169462
increased CD8-positive, alpha-beta memory T cell number J:169462
increased interferon-gamma secretion J:169462
increased interleukin-17 secretion J:169462
increased Paneth cell number J:169462
intestinal fibrosis J:169462
joint swelling J:169462
skin lesions J:169462
small intestinal inflammation J:169462
Tnfsf15tm1Cdon/Tnfsf15tm1Cdon
B6.129-Tnfsf15tm1Cdon 		abnormal dendritic cell differentiation J:136280
decreased susceptibility to experimental autoimmune encephalomyelitis J:136280
Tnfsf15tm1Hluo/Tnfsf15tm1Hluo
D1LacJ.129(B6)-Tnfsf15tm1Hluo 		decreased B cell number J:207029
decreased germinal center B cell number J:207029
decreased IgG2a level J:207029
decreased IgG2b level J:207029
decreased IgG level J:207029
decreased plasma cell number J:207029
decreased susceptibility to induced arthritis J:207029
decreased T cell number J:207029
decreased T follicular helper cell number J:207029
normal immune system phenotype J:207029
lymph node hypoplasia J:207029
Tnfsf15tm1Lex/Tnfsf15tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		increased NK cell number J:82809
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory