Pfkfb3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
MGI:2181202

26 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pfkfb3^tm1.1Pec/Pfkfb3^tm1.1Pec Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA	abnormal capillary morphology	J:296552
	abnormal carbohydrate metabolism	J:296552
	abnormal homeostasis	J:296552
	abnormal macrophage morphology	J:296552
	abnormal macrophage physiology	J:296552
	abnormal pH regulation	J:296552
	abnormal vascular development	J:296552
	normal cellular phenotype	J:296552
	decreased circulating lactate level	J:296552
	decreased glycogen catabolism rate	J:296552
	decreased skeletal muscle fiber diameter	J:296552
	decreased vascular endothelial cell number	J:296552
	gangrene	J:296552
	hypoxia	J:296552
	skeletal muscle necrosis	J:296552
Pfkfb3^{tm1b(EUCOMM)Wtsi}/Pfkfb3⁺ C57BL/6N-Pfkfb3^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal bone structure	J:211773
	decreased bone mineral density	J:211773
Pfkfb3^tm1Jche/Pfkfb3^tm1Jche B6.129-Pfkfb3^tm1Jche	embryonic lethality between implantation and somite formation, complete penetrance	J:97595
Tg(Myh6-Pfkfb3)7Pne/0 FVB-Tg(Myh6-Pfkfb3)7Pne	abnormal cardiovascular system physiology	J:94475
	abnormal glucose homeostasis	J:94475
	cardiac fibrosis	J:94475
	cardiac hypertrophy	J:94475
	decreased cardiac muscle cell glucose uptake	J:94475
	decreased cardiac muscle contractility	J:94475
	increased cardiac muscle glycogen level	J:94475
	increased heart weight	J:94475

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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