Pfkfb3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
MGI:2181202

26 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pfkfb3^tm1.1Pec/Pfkfb3^tm1.1Pec Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA	abnormal capillary morphology	J:296552
	abnormal carbohydrate metabolism	J:296552
	abnormal homeostasis	J:296552
	abnormal macrophage morphology	J:296552
	abnormal macrophage physiology	J:296552
	abnormal pH regulation	J:296552
	abnormal vascular development	J:296552
	normal cellular phenotype	J:296552
	decreased circulating lactate level	J:296552
	decreased glycogen catabolism rate	J:296552
	decreased skeletal muscle fiber diameter	J:296552
	decreased vascular endothelial cell number	J:296552
	gangrene	J:296552
	hypoxia	J:296552
	skeletal muscle necrosis	J:296552
Pfkfb3^{tm1b(EUCOMM)Wtsi}/Pfkfb3⁺ C57BL/6N-Pfkfb3^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal bone structure	J:211773
	decreased bone mineral density	J:211773
Pfkfb3^tm1Jche/Pfkfb3^tm1Jche B6.129-Pfkfb3^tm1Jche	embryonic lethality between implantation and somite formation, complete penetrance	J:97595
Tg(Myh6-Pfkfb3)7Pne/0 FVB-Tg(Myh6-Pfkfb3)7Pne	abnormal cardiovascular system physiology	J:94475
	abnormal glucose homeostasis	J:94475
	cardiac fibrosis	J:94475
	cardiac hypertrophy	J:94475
	decreased cardiac muscle cell glucose uptake	J:94475
	decreased cardiac muscle contractility	J:94475
	increased cardiac muscle glycogen level	J:94475
	increased heart weight	J:94475

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24