Ackr4 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ackr4
atypical chemokine receptor 4
MGI:2181676

11 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ackr4^tm1.1Rjbn/Ackr4^tm1.1Rjbn B6.129S6-Ackr4^tm1.1Rjbn	abnormal CD4-positive, alpha-beta T cell number	J:166490
	abnormal CD4-positive, alpha-beta T cell physiology	J:166490
	abnormal chemokine level	J:166490
	abnormal circulating chemokine level	J:166490
	abnormal T-helper 17 cell differentiation	J:166490
	decreased T cell proliferation	J:166490
	increased interleukin-23 secretion	J:166490
	increased susceptibility to experimental autoimmune encephalomyelitis	J:166490
	increased T-helper 17 cell number	J:166490
	spleen hyperplasia	J:166490
Ackr4^tm1Ccbl/Ackr4⁺ involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:182799
Ackr4^tm1Dgen/Ackr4^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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