Irak4 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irak4
interleukin-1 receptor-associated kinase 4
MGI:2182474

8 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irak4^m1Btlr/Irak4^m1Btlr Ptpn6^m1Btlr/Ptpn6^m1Btlr C57BL/6J-Ptpn6^m1Btlr Irak4^m1Btlr	normal immune system phenotype	J:142845
Irak4^m1Btlr/Irak4^m1Btlr Ticam1^Lps2/Ticam1^Lps2 involves: C57BL/6J	decreased tumor necrosis factor secretion	J:187583
Irak4^tm2Aki/Irak4^tm2Aki involves: 129X1/SvJ * C57BL/6	abnormal cytokine secretion	J:125729
	decreased B cell proliferation	J:125729
	decreased interferon-alpha secretion	J:125729
	decreased interleukin-6 secretion	J:125729
	decreased interleukin-12b secretion	J:125729
	decreased susceptibility to endotoxin shock	J:125729
	decreased tumor necrosis factor secretion	J:125729
	normal immune system phenotype	J:125729

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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