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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grhl2
grainyhead like transcription factor 2
MGI:2182543
50 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Grhl2clft3/Grhl2clft3
involves: A/J * FVB/N 		decreased brain size J:174027
encephalomeningocele J:174027
midline facial cleft J:174027
Grhl2em1(IMPC)Mbp/Grhl2+
C57BL/6N-Grhl2em1(IMPC)Mbp/MbpMmucd 		abnormal blood vessel morphology J:211773
abnormal placenta morphology J:211773
increased freezing behavior J:211773
increased startle reflex J:211773
Grhl2em1(IMPC)Mbp/Grhl2em1(IMPC)Mbp
C57BL/6N-Grhl2em1(IMPC)Mbp/MbpMmucd 		abnormal abdominal wall morphology J:211773
abnormal craniofacial morphology J:211773
abnormal forebrain development J:211773
abnormal head shape J:211773
abnormal heart morphology J:211773
abnormal hindbrain development J:211773
abnormal limb morphology J:211773
abnormal midbrain development J:211773
abnormal neural tube closure J:211773
abnormal neural tube morphology J:211773
abnormal optic vesicle formation J:211773
abnormal pericardium morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta size J:211773
embryonic growth retardation J:211773
exencephaly J:211773
preweaning lethality, complete penetrance J:211773
syndactyly J:211773
Grhl2Gt(AC0205)Wtsi/Grhl2+
involves: 129P2/OlaHsd * C57BL/6 		exencephaly J:170759
facial cleft J:170759
incomplete rostral neuropore closure J:170759
Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal neural tube closure J:170759
embryonic lethality during organogenesis, complete penetrance J:170759
exencephaly J:170759
facial cleft J:170759
incomplete rostral neuropore closure J:170759
spina bifida J:170759
Grhl2Gt(AC0205)Wtsi/Grhl2Gt(AC0205)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:170759
Grhl2Gt(E115B04)Wrst/Grhl2Gt(E115B04)Wrst
involves: 129P2/OlaHsd * C57BL/6 		abnormal neural fold elevation formation J:167065
curly tail J:167065
embryonic growth retardation J:167065
embryonic lethality during organogenesis, complete penetrance J:167065
everted embryonic neuroepithelium J:167065
exencephaly J:167065
facial cleft J:167065
incomplete caudal neuropore closure J:167065
incomplete rostral neuropore closure J:167065
spina bifida J:167065
Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal neural fold elevation formation J:167065
curly tail J:167065
embryonic growth retardation J:167065
embryonic lethality during organogenesis, complete penetrance J:167065
everted embryonic neuroepithelium J:167065
exencephaly J:167065
facial cleft J:167065
incomplete caudal neuropore closure J:167065
incomplete rostral neuropore closure J:167065
spina bifida J:167065
Grhl2m1Nisw/Grhl2m1Nisw
129S1.B6-Grhl2m1Nisw 		abnormal heart morphology J:169829
abnormal heart ventricle morphology J:169829
abnormal respiratory conducting tube morphology J:169829
decreased embryo size J:169829
decreased litter size J:169829
embryonic growth retardation J:169829
embryonic lethality during organogenesis, incomplete penetrance J:169829
exencephaly J:169829
facial cleft J:169829
lethality, incomplete penetrance J:169829
open neural tube J:169829
small lung lobe J:169829
thin ventricular wall J:169829
thoracoabdominoschisis J:169829
Grhl2m1Nisw/Grhl2m1Nisw
involves: C3HeB/FeJ * C57BL/6J 		abnormal body wall morphology J:169829
abnormal cranium morphology J:169829
abnormal midface morphology J:169829
coloboma J:169829
exencephaly J:169829
facial cleft J:169829
interdigital webbing J:169829
lethality throughout fetal growth and development, complete penetrance J:169829
lethality, incomplete penetrance J:169829
open neural tube J:169829
split sternum J:169829
syndactyly J:169829
Grhl2tm1.1Jane/Grhl2tm1.1Jane
involves: 129S1/Sv * BALB/cJ * C57BL/6 		abnormal neural fold elevation formation J:164805
cranioschisis J:164805
embryonic lethality during organogenesis, complete penetrance J:164805
facial cleft J:164805
incomplete caudal neuropore closure J:164805
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory