Rspo1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rspo1
R-spondin 1
MGI:2183426

28 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rspo1^{tm1.1(KOMP)Vlcg}/Rspo1^{tm1.1(KOMP)Vlcg} C57BL/6N-Rspo1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal kidney morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal vibrissa morphology	J:211773
	decreased brain weight	J:211773
	decreased total body fat amount	J:211773
	female infertility	J:211773
	increased bone mineral content	J:211773
	increased grip strength	J:211773
	increased lean body mass	J:211773
	small testis	J:211773
Rspo1^tm1.1Ktom/Rspo1^tm1.1Ktom involves: C57BL/6 * CBA	abnormal ovary development	J:133934
	abnormal ovary secretion	J:133934
	decreased mature ovarian follicle number	J:133934
	decreased oocyte number	J:133934
	pseudohermaphroditism	J:133934
	reduced female fertility	J:133934
Rspo1^tm1Mcch/Rspo1^tm1Mcch involves: 129 * C57BL/6J	abnormal female meiosis	J:133933
	abnormal ovary development	J:133933
	pseudohermaphroditism	J:133933
Rspo1^tm1Mcch/Rspo1^tm1Mcch involves: 129/Sv * C57BL/6J	abnormal germ cell morphology	J:203797
	abnormal oogenesis	J:203797
	decreased oocyte number	J:203797
	decreased primordial ovarian follicle number	J:203797
Rspo1^{tm2b(KOMP)Wtsi}/Rspo1^{tm2b(KOMP)Wtsi} C57BL/6N-Rspo1^{tm2b(KOMP)Wtsi}/Ics	abnormal eye anterior chamber depth	J:211773
	abnormal retina outer nuclear layer morphology	J:211773
	abnormal vitreous body morphology	J:211773
	decreased lean body mass	J:211773
	decreased total retina thickness	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating creatinine level	J:211773
	increased lymphocyte cell number	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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