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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nrbp1
nuclear receptor binding protein 1
MGI:2183436
27 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nrbp1tm1.1Dja/Nrbp1tm1.1Dja
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
abnormal crypts of Lieberkuhn morphology J:184685
abnormal enterocyte proliferation J:184685
abnormal intestinal enteroendocrine cell morphology J:184685
abnormal intestinal goblet cell morphology J:184685
abnormal intestinal mucosa morphology J:184685
abnormal intestine morphology J:184685
abnormal liver morphology J:184685
decreased tumor-free survival time J:184685
distended stomach J:184685
ectopic Paneth cells J:184685
increased gastrointestinal tumor incidence J:184685
increased leukemia incidence J:184685
increased lung carcinoma incidence J:184685
increased lymphoma incidence J:184685
increased tumor incidence J:184685
intestinal edema J:184685
Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
abnormal crypts of Lieberkuhn morphology J:184685
abnormal enterocyte proliferation J:184685
abnormal intestinal enteroendocrine cell morphology J:184685
abnormal intestinal goblet cell morphology J:184685
abnormal intestinal mucosa morphology J:184685
abnormal intestine morphology J:184685
abnormal liver morphology J:184685
decreased tumor-free survival time J:184685
distended stomach J:184685
ectopic Paneth cells J:184685
increased gastrointestinal tumor incidence J:184685
increased leukemia incidence J:184685
increased lung carcinoma incidence J:184685
increased lymphoma incidence J:184685
increased tumor incidence J:184685
intestinal edema J:184685
Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
abnormal intestinal goblet cell morphology J:184685
abnormal intestine morphology J:184685
abnormal Paneth cell morphology J:184685
ectopic Paneth cells J:184685
Nrbp1tm1.2Dja/Nrbp1tm1.2Dja
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
embryonic lethality between implantation and somite formation, complete penetrance J:184685
Nrbp1tm3b(EUCOMM)Wtsi/Nrbp1+
C57BL/6N-Nrbp1tm3b(EUCOMM)Wtsi/Wtsi
decreased CD4-positive, alpha-beta T cell number J:211773
increased CD8-positive, alpha-beta T cell number J:211773
increased grip strength J:211773
Nrbp1tm3b(EUCOMM)Wtsi/Nrbp1tm3b(EUCOMM)Wtsi
C57BL/6N-Nrbp1tm3b(EUCOMM)Wtsi/Wtsi
abnormal chorion morphology J:261316
abnormal placenta morphology J:261316
abnormal trophoblast giant cell morphology J:261316
abnormal trophoblast layer morphology J:261316
lethality throughout fetal growth and development, complete penetrance J:261316
preweaning lethality, complete penetrance J:211773

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory