Il27 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il27
interleukin 27
MGI:2384409

8 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il27^{tm1b(EUCOMM)Wtsi}/Il27^{tm1b(EUCOMM)Wtsi} C57BL/6N-Il27^{tm1b(EUCOMM)Wtsi}/Wtsi	decreased CD4-positive, alpha-beta memory T cell number	J:211773
	increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:211773
Il27^tm1Cua/Il27^tm1Cua C57BL/6-Il27^tm1Cua	abnormal CD4-positive T cell differentiation	J:147706
	increased susceptibility to experimental autoimmune encephalomyelitis	J:147706
	increased susceptibility to type IV hypersensitivity reaction	J:147706
Il27^tm1Lex/Il27^tm1Lex involves: 129S/SvEvBrd	increased circulating interleukin-12b level	J:187660
	increased interferon-gamma secretion	J:187660
	increased susceptibility to parasitic infection induced morbidity/mortality	J:187660

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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