Aars1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aars1
alanyl-tRNA synthetase 1
MGI:2384560

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aars1^sti/Aars1^sti B6.Cg-Aars1^sti/J	abnormal hair shaft morphology	J:110647
	ataxia	J:110647
	disheveled coat	J:110647
	focal hair loss	J:110647
	hair follicle degeneration	J:110647
	hair follicle outer root sheath hyperplasia	J:110647
	impaired balance	J:110647
	normal nervous system phenotype	J:220153
	Purkinje cell degeneration	J:110647
	tremors	J:110647
Aars1^sti/Aars1^tm1.1Slac involves: C57BL/6J * FVB/N	abnormal myocardial fiber morphology	J:216802
	alopecia	J:216802
	cardiac fibrosis	J:216802
	decreased body size	J:216802
Aars1^sti/Aars1^tm1Slac involves: C57BL/6J	abnormal autophagy	J:216802
	abnormal cardiovascular system physiology	J:216802
	abnormal myocardial fiber mitochondrial morphology	J:216802
	abnormal myocardial fiber morphology	J:216802
	abnormal myocardial fiber physiology	J:216802
	abnormal sarcoplasmic reticulum morphology	J:216802
	alopecia	J:216802
	cardiac fibrosis	J:216802
	cardiac interstitial fibrosis	J:216802
	decreased body size	J:216802
	decreased body weight	J:216802
	decreased cardiac output	J:216802
	decreased heart left ventricle muscle contractility	J:216802
	decreased heart left ventricle posterior wall thickness	J:216802
	myocardial fiber disarray	J:216802
	Purkinje cell degeneration	J:216802
	small heart	J:216802
Aars1^tm1.1Slac/Aars1⁺ involves: C57BL/6J * FVB/N	Purkinje cell degeneration	J:216802
Aars1^tm1.1Slac/Aars1^tm1.1Slac involves: C57BL/6J * FVB/N	embryonic lethality prior to organogenesis, complete penetrance	J:216802

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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