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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Aars1
alanyl-tRNA synthetase 1
MGI:2384560
32 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aars1em1(IMPC)Bay/Aars1+
C57BL/6N-Aars1em1(IMPC)Bay/Bay 		abnormal head morphology J:211773
abnormal tail length J:211773
decreased total body fat amount J:211773
increased lean body mass J:211773
Aars1em1(IMPC)Bay/Aars1em1(IMPC)Bay
C57BL/6N-Aars1em1(IMPC)Bay/Bay 		preweaning lethality, complete penetrance J:211773
Aars1sti/Aars1sti
B6.Cg-Aars1sti/J 		abnormal hair shaft morphology J:110647
ataxia J:110647
disheveled coat J:110647
focal hair loss J:110647
hair follicle degeneration J:110647
hair follicle outer root sheath hyperplasia J:110647
impaired balance J:110647
normal nervous system phenotype J:220153
Purkinje cell degeneration J:110647
tremors J:110647
Aars1sti/Aars1tm1.1Slac
involves: C57BL/6J * FVB/N 		abnormal myocardial fiber morphology J:216802
alopecia J:216802
cardiac fibrosis J:216802
decreased body size J:216802
Aars1sti/Aars1tm1Slac
involves: C57BL/6J 		abnormal autophagy J:216802
abnormal cardiovascular system physiology J:216802
abnormal myocardial fiber mitochondrial morphology J:216802
abnormal myocardial fiber morphology J:216802
abnormal myocardial fiber physiology J:216802
abnormal sarcoplasmic reticulum morphology J:216802
alopecia J:216802
cardiac fibrosis J:216802
cardiac interstitial fibrosis J:216802
decreased body size J:216802
decreased body weight J:216802
decreased cardiac output J:216802
decreased heart left ventricle muscle contractility J:216802
decreased heart left ventricle posterior wall thickness J:216802
myocardial fiber disarray J:216802
Purkinje cell degeneration J:216802
small heart J:216802
Aars1tm1.1Slac/Aars1+
involves: C57BL/6J * FVB/N 		Purkinje cell degeneration J:216802
Aars1tm1.1Slac/Aars1tm1.1Slac
involves: C57BL/6J * FVB/N 		embryonic lethality prior to organogenesis, complete penetrance J:216802
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory