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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nae1
NEDD8 activating enzyme E1 subunit 1
MGI:2384561
35 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nae1tm1b(EUCOMM)Wtsi/Nae1+
C57BL/6N-Nae1tm1b(EUCOMM)Wtsi/Ics 		decreased erythrocyte cell number J:211773
decreased exploration in new environment J:211773
increased circulating phosphate level J:211773
increased fasting circulating glucose level J:211773
increased mean corpuscular volume J:211773
Nae1tm1b(EUCOMM)Wtsi/Nae1tm1b(EUCOMM)Wtsi
C57BL/6N-Nae1tm1b(EUCOMM)Wtsi/Ics 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Nae1tm1c(EUCOMM)Wtsi/Nae1tm1c(EUCOMM)Wtsi
Tg(Camk2a-cre/ERT2)2Gsc/0
Tg(Thy1-EGFP)MJrs/0
involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL 		abnormal CNS synaptic transmission J:262411
abnormal dendritic spine morphology J:262411
abnormal spatial working memory J:262411
normal behavior/neurological phenotype J:262411
decreased dendritic spine density J:262411
impaired long-term object recognition memory J:262411
impaired short-term object recognition memory J:262411
Nae1tm1c(EUCOMM)Wtsi/Nae1tm1c(EUCOMM)Wtsi
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6J * C57BL/6N * FVB/N * SJL 		abnormal heart development J:261328
abnormal myocardium layer morphology J:261328
cardiac hypertrophy J:261328
cyanosis J:261328
decreased fetal cardiomyocyte proliferation J:261328
decreased heart left ventricle wall thickness J:261328
decreased heart rate J:261328
decreased heart ventricle muscle contractility J:261328
dilated heart left ventricle J:261328
dilated heart right ventricle J:261328
enlarged heart J:261328
extremity edema J:261328
increased heart weight J:261328
increased myocardial fiber size J:261328
myocardial hypertrabeculation J:261328
myocardial ventricular hypertrabeculation J:261328
myocardium hypoplasia J:261328
postnatal lethality, complete penetrance J:261328
thin left ventricle myocardium compact layer J:261328
thin ventricle myocardium compact layer J:261328
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory