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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdk5rap2
CDK5 regulatory subunit associated protein 2
MGI:2384875
54 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdk5rap2an/Cdk5rap2an
B6.Cg-Cdk5rap2an 		abnormal cerebral cortex morphology J:160533
abnormal embryonic/fetal subventricular zone morphology J:160533
abnormal forebrain development J:160533
abnormal mitosis J:160533
abnormal mitotic spindle morphology J:160533
abnormal neuron proliferation J:160533
decreased body size J:160533
decreased brain size J:160533
enlarged brain ventricles J:160533
increased neuron apoptosis J:160533
loss of cortex neurons J:160533
microcephaly J:160533
premature death J:160533
small hippocampus J:160533
small olfactory bulb J:160533
thin cerebral cortex J:160533
Cdk5rap2an/Cdk5rap2an
involves: C57BL/6 * WB 		abnormal cerebral cortex morphology J:160533
Cdk5rap2an/Cdk5rap2an
Not Specified 		abnormal erythrocyte morphology J:5439
abnormal erythropoiesis J:5439
abnormal spermatogenesis J:22618
anemia J:208
anisocytosis J:5439
decreased body size J:208, J:5439
decreased germ cell number J:15165
decreased leukocyte cell number J:5439
decreased oocyte number J:15165
eye opacity J:22618
increased ovary adenoma incidence J:15165
kyphosis J:22618
macrocytic anemia J:5439
macrocytosis J:5439
postnatal lethality J:208, J:5439
premature hair loss J:22618
reduced fertility J:5439, J:22618
reticulocytopenia J:5439
Cdk5rap2em1Mama/Cdk5rap2em1Mama
involves: C57BL/6 * C57BL/6J * CBA 		abnormal male germ cell physiology J:310617
abnormal neocortex morphology J:310617
abnormal retina development J:310617
normal cellular phenotype J:310617
decreased brain weight J:310617
microphthalmia J:310617
Cdk5rap2Gt(RRF465)Byg/Cdk5rap2Gt(RRF465)Byg
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cell nucleus morphology J:163849
abnormal centrosome morphology J:163849
abnormal microtubule organizing center morphology J:163849
abnormal mitosis J:163849
abnormal mitotic spindle morphology J:163849
abnormal pericentriolar material morphology J:163849
abnormal plasma membrane morphology J:163849
early cellular replicative senescence J:163849
male infertility J:163849
Cdk5rap2Gt(RRO242)Byg/Cdk5rap2+
involves: 129P2/OlaHsd * C57BL/6J 		decreased leukocyte cell number J:160533
Cdk5rap2Gt(RRO242)Byg/Cdk5rap2an
involves: 129P2/OlaHsd * C57BL/6J 		decreased erythrocyte cell number J:160533
decreased leukocyte cell number J:160533
macrocytic anemia J:160533
Cdk5rap2Gt(RRU031)Byg/Cdk5rap2Gt(RRU031)Byg
involves: 129P2/OlaHsd * C57BL/6J 		abnormal centrosome morphology J:163849
abnormal pericentriolar material morphology J:163849
normal cellular phenotype J:163849
Cdk5rap2tm1a(EUCOMM)Wtsi/Cdk5rap2tm1a(EUCOMM)Wtsi
C57BL/6N-Cdk5rap2tm1a(EUCOMM)Wtsi/Wtsi 		abnormal cranium morphology J:175295
abnormal head morphology J:175295
decreased body weight J:175295
decreased bone mineral content J:175295
decreased lean body mass J:175295
decreased leukocyte cell number J:175295
increased mean corpuscular hemoglobin J:175295
increased mean corpuscular volume J:175295
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory