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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
MGI:2384876
43 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdc73Gt(RRE190)Byg/Cdc73+
B6.129P2-Cdc73Gt(RRE190)Byg 		abnormal jaw morphology J:243366
abnormal myometrium morphology J:243366
endometrium hyperplasia J:243366
increased activity of parathyroid J:243366
increased circulating calcium level J:243366
increased circulating parathyroid hormone level J:243366
increased parathyroid adenoma incidence J:243366
increased parathyroid gland tumor incidence J:243366
increased uterus tumor incidence J:243366
premature death J:243366
uterus cyst J:243366
Cdc73Gt(RRE190)Byg/Cdc73Gt(RRE190)Byg
involves: 129P2/OlaHsd 		absent inner cell mass proliferation J:135255
absent trophectoderm cell proliferation J:135255
embryonic lethality before implantation, complete penetrance J:135255
failure of embryo implantation J:135255
Cdc73tm1.1Btt/Cdc73tm1.1Btt
involves: 129S4/SvJae * BALB/cJ 		embryonic lethality, complete penetrance J:135255
Cdc73tm1Btt/Cdc73+
Tg(PTH-cre)4167Slib/0
Not Specified 		increased circulating calcium level J:243366
increased parathyroid adenoma incidence J:243366
increased parathyroid gland tumor incidence J:243366
Cdc73tm1Btt/Cdc73tm1Btt
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal digestive system morphology J:135255
abnormal gland physiology J:135255
abnormal nervous system development J:135255
abnormal reflex J:135255
ascites J:135255
decreased abdominal adipose tissue amount J:135255
decreased cell proliferation J:135255
decreased embryo size J:135255
decreased locomotor activity J:135255
decreased pulmonary respiratory rate J:135255
decreased skeletal muscle mass J:135255
decreased subcutaneous adipose tissue amount J:135255
hepatic necrosis J:135255
increased apoptosis J:135255
increased fibroblast apoptosis J:135255
premature death J:135255
prenatal lethality, complete penetrance J:135255
renal necrosis J:135255
small heart J:135255
small kidney J:135255
small liver J:135255
small lung J:135255
small salivary gland J:135255
small seminal vesicle J:135255
small spleen J:135255
small stomach J:135255
small testis J:135255
weight loss J:135255
Cdc73tm1Btt/Cdc73tm1Btt
Tg(PTH-cre)4167Slib/0
Not Specified 		increased circulating calcium level J:243366
increased parathyroid adenoma incidence J:243366
increased parathyroid gland tumor incidence J:243366
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory