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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spns2
SPNS lysolipid transporter 2, sphingosine-1-phosphate
MGI:2384936
74 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Spns2tm1.1Nmoc/Spns2tm1.1Nmoc
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL 		abnormal B cell physiology J:184558
abnormal effector T cell morphology J:184558
abnormal T cell physiology J:184558
decreased CD4-positive, alpha-beta T cell number J:184558
decreased CD8-positive, alpha-beta T cell number J:184558
decreased mature B cell number J:184558
increased CD4-positive, alpha-beta T cell number J:184558
increased CD8-positive, alpha-beta T cell number J:184558
normal vision/eye phenotype J:184558
Spns2tm1.2Nmoc/Spns2tm1.2Nmoc
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal B cell physiology J:184558
abnormal T cell physiology J:184558
decreased B-1 B cell number J:184558
decreased CD4-positive, alpha-beta T cell number J:184558
decreased CD8-positive, alpha-beta T cell number J:184558
decreased follicular B cell number J:184558
decreased immature B cell number J:184558
decreased leukocyte cell number J:184558
decreased mature B cell number J:184558
decreased transitional stage T1 B cell number J:184558
increased CD4-positive, alpha-beta T cell number J:184558
increased CD8-positive, alpha-beta T cell number J:184558
increased single-positive T cell number J:184558
symblepharon J:184558
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi 		abnormal behavior J:175295
abnormal cornea morphology J:165965
abnormal eye morphology J:165965
abnormal eye pigmentation J:165965
abnormal eye size J:165965
abnormal eyelid aperture J:165965
abnormal iris morphology J:165965
abnormal rib morphology J:165965
absent pinna reflex J:165965
cornea opacity J:165965
cornea vascularization J:165965
decreased leukocyte cell number J:165965
decreased lumbar vertebrae number J:165965
excessive tearing J:165965
increased bone mineral density J:165965
increased sacral vertebrae number J:165965
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N 		abnormal auditory brainstem response J:213427
abnormal ciliary body morphology J:213427
abnormal cornea morphology J:213427
abnormal cornea stroma morphology J:213427
abnormal eye pigmentation J:188933, J:213427
abnormal humoral immune response J:188933
abnormal iridocorneal angle J:213427
abnormal iris morphology J:213427
abnormal pupil morphology J:213427
abnormal retina morphology J:213427
absent pinna reflex J:213427
cataract J:213427
cornea opacity J:213427
cornea vascularization J:213427
decreased B cell number J:188933, J:213427
decreased B-1 B cell number J:188933
decreased CD4-positive, alpha-beta T cell number J:188933, J:213427
decreased CD8-positive, alpha-beta T cell number J:188933, J:213427
decreased circulating glucose level J:213427
decreased follicular B cell number J:188933
decreased IgG1 level J:188933
decreased IgG level J:188933
decreased leukocyte cell number J:188933, J:213427
decreased mature B cell number J:213427
decreased T cell number J:213427
eye opacity J:188933, J:213427
eyelids fail to open J:213427
normal immune system phenotype J:188933
increased bone mineral content J:213427
increased bone strength J:213427
increased CD4-positive, alpha-beta T cell number J:188933
increased CD8-positive, alpha-beta T cell number J:188933
increased circulating bilirubin level J:213427
increased granulocyte number J:213427
increased incidence of corneal inflammation J:213427
increased monocyte cell number J:213427
increased NK cell number J:213427
increased NK T cell number J:213427
increased susceptibility to bacterial infection J:213427
microphthalmia J:213427
narrow eye opening J:213427
small lens J:213427
Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Spns2tm1b(KOMP)Wtsi/WtsiH 		abnormal cornea morphology J:211773
abnormal iris morphology J:211773
absent pinna reflex J:211773
cornea opacity J:211773
cornea vascularization J:211773
decreased bone mineral content J:211773
decreased leukocyte cell number J:211773
increased mean corpuscular hemoglobin J:211773
narrow eye opening J:211773
trunk curl J:211773
Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N 		decreased B cell number J:188933
decreased CD4-positive, alpha-beta T cell number J:188933
decreased CD8-positive, alpha-beta T cell number J:188933
increased CD4-positive, alpha-beta T cell number J:188933
increased CD8-positive, alpha-beta T cell number J:188933
Spns2tm1c(KOMP)Wtsi/Spns2tm1c(KOMP)Wtsi
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N 		normal immune system phenotype J:188933
Spns2tm1Tni/Spns2tm1Tni
B6.Cg-Spns2tm1Tni 		abnormal leukocyte cell number J:225108
abnormal mature B cell number J:225108
abnormal thymus morphology J:225108
decreased body weight J:225108
decreased leukocyte cell number J:225108
decreased lymphocyte cell number J:225108
decreased monocyte cell number J:225108
decreased single-positive T cell number J:225108
decreased sphingosine level J:225108
decreased survivor rate J:225108
decreased thymocyte number J:225108
eyelids open at birth J:225108
normal growth/size/body region phenotype J:225108
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory