Ncoa5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ncoa5
nuclear receptor coactivator 5
MGI:2385165

31 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ncoa5^{tm1.1(KOMP)Mbp}/Ncoa5⁺ C57BL/6N-Ncoa5^{tm1.1(KOMP)Mbp}/Tcp	increased eosinophil cell number	J:211773
	increased heart weight	J:211773
Ncoa5^{tm1.1(KOMP)Mbp}/Ncoa5^{tm1.1(KOMP)Mbp} C57BL/6N-Ncoa5^{tm1.1(KOMP)Mbp}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Ncoa5^tm1Hxia/Ncoa5⁺ C.129(B6)-Ncoa5^tm1Hxia	impaired glucose tolerance	J:207622
	increased fasting circulating glucose level	J:207622
	increased hepatocellular carcinoma incidence	J:207622
Ncoa5^tm1Hxia/Ncoa5⁺ involves: 129 * C57BL/6	abnormal circulating protein level	J:207622
	abnormal epididymis physiology	J:284227
	abnormal liver morphology	J:207622
	abnormal sperm head morphology	J:284227
	abnormal sperm midpiece morphology	J:284227
	abnormal sperm mitochondrial morphology	J:284227
	asthenozoospermia	J:284227
	chronic liver inflammation	J:207622
	decreased pancreatic islet number	J:207622
	decreased sperm progressive motility	J:284227
	hepatic steatosis	J:207622
	normal homeostasis/metabolism phenotype	J:207622
	impaired glucose tolerance	J:207622
	increased circulating alanine transaminase level	J:207622
	increased fasting circulating glucose level	J:207622
	increased hepatocellular carcinoma incidence	J:207622
	increased hepatocyte apoptosis	J:207622
	increased hepatocyte proliferation	J:207622
	increased liver triglyceride level	J:207622
	insulin resistance	J:207622
	liver fibrosis	J:207622
	male infertility	J:207622, J:284227
	reduced male fertility	J:284227
	normal reproductive system phenotype	J:207622
	small pancreatic islets	J:207622
	teratozoospermia	J:284227

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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