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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fras1
Fraser extracellular matrix complex subunit 1
MGI:2385368
69 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fras1b2b3323Clo/Fras1b2b3323Clo
C57BL/6J-Fras1b2b3323Clo 		abnormal digit morphology J:175213
abnormal eye morphology J:175213
absent kidney J:175213
micrognathia J:175213
perimembraneous ventricular septal defect J:175213
Fras1bfb/Fras1bfb
involves: C3H/HeH * C57BL/6JAnu 		absent kidney J:199856
bleb J:199856
cleft secondary palate J:199856
eyelids open at birth J:199856
preaxial polydactyly J:199856
Fras1bfb/Fras1bfb
involves: C57BL/6JAnu 		abnormal palatal shelf fusion at midline J:208682
abnormal palatal shelf morphology J:208682
abnormal rib morphology J:208682
abnormal sternebra morphology J:208682
abnormal sternum morphology J:208682
absent kidney J:208682
bleb J:208682
blistering J:208682
cleft secondary palate J:208682
complete cleft palate J:208682
normal craniofacial phenotype J:208682
narrow eye opening J:208682
preaxial polydactyly J:208682
small kidney J:208682
subcutaneous hemorrhage J:208682
Fras1bl/Fras1bl
involves: 101/H * C3H/HeH 		abnormal basement membrane morphology J:83745
abnormal hair growth J:13501
abnormal kidney development J:83745
abnormal metanephric mesenchyme morphology J:83745
abnormal metanephros morphology J:83745
abnormal ureteric bud morphology J:83745
absent kidney J:13501, J:83745
bleb J:13501
clubfoot J:13501, J:83745
cryptophthalmos J:83745
delayed kidney development J:83745
fetal bleb J:83745
impaired branching involved in ureteric bud morphogenesis J:83745
increased metanephric mesenchyme apoptosis J:83745
kidney cyst J:83745
microphthalmia J:13501
prenatal lethality, incomplete penetrance J:83745
single kidney J:13501, J:83745
small kidney J:83745
syndactyly J:83745
Fras1bl/Fras1tm1.2Pjsc
involves: 101/H * C3H/HeH * C57BL/6 * FVB/N * SJL 		abnormal glomerular capillary morphology J:190659
abnormal glomerular capsule space morphology J:190659
abnormal glomerular mesangium morphology J:190659
abnormal renal glomerulus morphology J:190659
cortical renal glomerulopathies J:190659
glomerulosclerosis J:190659
normal integument phenotype J:190659
normal renal/urinary system phenotype J:190659
Fras1em1(IMPC)Ccpcz/Fras1+
C57BL/6NCrl-Fras1em1(IMPC)Ccpcz/Ccpcz 		abnormal spleen morphology J:211773
abnormal vertebrae morphology J:211773
increased airway resistance J:211773
increased freezing behavior J:211773
increased lung tissue damping J:211773
Fras1em1(IMPC)Ccpcz/Fras1em1(IMPC)Ccpcz
C57BL/6NCrl-Fras1em1(IMPC)Ccpcz/Ccpcz 		preweaning lethality, incomplete penetrance J:211773
Fras1rdf/Fras1rdf
involves: C57BL/6J * FVB/NJ 		abnormal digit morphology J:231083
abnormal eye morphology J:231083
abnormal hindlimb morphology J:231083
abnormal interdigital cell death J:231083
abnormal limb morphology J:231083
abnormal tail tip morphology J:231083
absent kidney J:231083
blistering J:231083
cleft palate J:231083
decreased body size J:231083
eyelids open at birth J:231083
flaky skin J:231083
postnatal growth retardation J:231083
postnatal lethality, complete penetrance J:231083
preaxial polydactyly J:231083
short tail J:231083
single kidney J:231083
syndactyly J:231083
Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
involves: C57BL/6 * FVB/N * SJL 		absent kidney J:190659
blistering J:190659
hemorrhage J:190659
Fras1tm1Chpk/Fras1tm1Chpk
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 		absent kidney J:83746
blistering J:83746
cryptophthalmos J:83746
lethality throughout fetal growth and development, complete penetrance J:83746
lethality throughout fetal growth and development, incomplete penetrance J:83746
syndactyly J:83746
Fras1tm1Chpk/Fras1tm1Chpk
involves: 129S1/Sv * 129X1/SvJ * NMRI 		abnormal basement membrane morphology J:137010
abnormal lung development J:137010
abnormal lung epithelium morphology J:137010
abnormal lung morphology J:137010
abnormal lung vasculature morphology J:137010
fused right lung lobes J:137010
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory