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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zc3h12a
zinc finger CCCH type containing 12A
MGI:2385891
50 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Zc3h12atm1Aki/Zc3h12atm1Aki
involves: 129X1/SvJ * C57BL/6 		abnormal acute inflammation J:147868
abnormal cell physiology J:147868
abnormal class switch recombination J:147868
abnormal proerythroblast morphology J:147868
anemia J:147868
decreased hematocrit J:147868
decreased hemoglobin content J:147868
enlarged lymph nodes J:147868
enlarged spleen J:147868
granulomatous inflammation J:147868
increased anti-double stranded DNA antibody level J:147868
increased anti-nuclear antigen antibody level J:147868
increased IgA level J:147868
increased IgG1 level J:147868
increased IgG2a level J:147868
increased IgG2b level J:147868
increased IgG3 level J:147868
increased IgM level J:147868
increased immunoglobulin level J:147868
increased interferon-gamma secretion J:147868
increased interleukin-6 secretion J:147868
increased interleukin-12b secretion J:147868
increased leukocyte cell number J:147868
increased memory T cell number J:147868
increased plasma cell number J:147868
postnatal growth retardation J:147868
premature death J:147868
thrombocytosis J:147868
Zc3h12atm1b(EUCOMM)Hmgu/Zc3h12a+
C57BL/6N-Zc3h12atm1b(EUCOMM)Hmgu/Ieg 		increased circulating lipase level J:211773
Zc3h12atm1b(EUCOMM)Hmgu/Zc3h12atm1b(EUCOMM)Hmgu
C57BL/6N-Zc3h12atm1b(EUCOMM)Hmgu/Ieg 		preweaning lethality, incomplete penetrance J:211773
Zc3h12atm1c(EUCOMM)Hmgu/Zc3h12atm1c(EUCOMM)Hmgu
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6N 		increased inflammatory response J:304105
normal liver/biliary system phenotype J:304105
Zc3h12atm1c(EUCOMM)Hmgu/Zc3h12atm1c(EUCOMM)Hmgu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6N * DBA 		abnormal bile duct epithelium morphology J:304105
abnormal bile duct physiology J:304105
abnormal liver parenchyma morphology J:304105
bile duct hyperplasia J:304105
bile duct inflammation J:304105
enlarged liver J:304105
enlarged spleen J:304105
granulomatous inflammation J:304105
increased anti-nuclear antigen antibody level J:304105
increased autoantibody level J:304105
increased bile salt level J:304105
increased circulating alkaline phosphatase level J:304105
increased IgG level J:304105
increased IgM level J:304105
intrahepatic cholestasis J:304105
liver fibrosis J:304105
liver inflammation J:304105
Zc3h12atm1Fum/Zc3h12atm1Fum
C57BL/6-Zc3h12atm1Fum 		abnormal chemokine secretion J:176866
abnormal circulating chemokine level J:176866
enlarged lymph nodes J:176866
enlarged spleen J:176866
increased circulating tumor necrosis factor level J:176866
increased interleukin-1 beta secretion J:176866
increased interleukin-6 secretion J:176866
increased tumor necrosis factor secretion J:176866
postnatal growth retardation J:176866
premature death J:176866
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory