Zc3h12a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Zc3h12a
zinc finger CCCH type containing 12A
MGI:2385891

52 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Zc3h12a^tm1Aki/Zc3h12a^tm1Aki involves: 129X1/SvJ * C57BL/6	abnormal acute inflammation	J:147868
	abnormal cell physiology	J:147868
	abnormal class switch recombination	J:147868
	abnormal proerythroblast morphology	J:147868
	anemia	J:147868
	decreased hematocrit	J:147868
	decreased hemoglobin content	J:147868
	enlarged lymph nodes	J:147868
	enlarged spleen	J:147868
	granulomatous inflammation	J:147868
	increased anti-double stranded DNA antibody level	J:147868
	increased anti-nuclear antigen antibody level	J:147868
	increased IgA level	J:147868
	increased IgG1 level	J:147868
	increased IgG2a level	J:147868
	increased IgG2b level	J:147868
	increased IgG3 level	J:147868
	increased IgM level	J:147868
	increased immunoglobulin level	J:147868
	increased interferon-gamma secretion	J:147868
	increased interleukin-6 secretion	J:147868
	increased interleukin-12b secretion	J:147868
	increased leukocyte cell number	J:147868
	increased memory T cell number	J:147868
	increased plasma cell number	J:147868
	postnatal growth retardation	J:147868
	premature death	J:147868
	thrombocytosis	J:147868
Zc3h12a^{tm1b(EUCOMM)Hmgu}/Zc3h12a⁺ C57BL/6N-Zc3h12a^{tm1b(EUCOMM)Hmgu}/Ieg	increased circulating lipase level	J:211773
	increased circulating phosphate level	J:211773
	increased mean corpuscular volume	J:211773
Zc3h12a^{tm1b(EUCOMM)Hmgu}/Zc3h12a^{tm1b(EUCOMM)Hmgu} C57BL/6N-Zc3h12a^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, incomplete penetrance	J:211773
Zc3h12a^{tm1c(EUCOMM)Hmgu}/Zc3h12a^{tm1c(EUCOMM)Hmgu} Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6N	increased inflammatory response	J:304105
	normal liver/biliary system phenotype	J:304105
Zc3h12a^{tm1c(EUCOMM)Hmgu}/Zc3h12a^{tm1c(EUCOMM)Hmgu} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6N * DBA	abnormal bile duct epithelium morphology	J:304105
	abnormal bile duct physiology	J:304105
	abnormal liver parenchyma morphology	J:304105
	bile duct hyperplasia	J:304105
	bile duct inflammation	J:304105
	enlarged liver	J:304105
	enlarged spleen	J:304105
	granulomatous inflammation	J:304105
	increased anti-nuclear antigen antibody level	J:304105
	increased autoantibody level	J:304105
	increased bile salt level	J:304105
	increased circulating alkaline phosphatase level	J:304105
	increased IgG level	J:304105
	increased IgM level	J:304105
	intrahepatic cholestasis	J:304105
	liver fibrosis	J:304105
	liver inflammation	J:304105
Zc3h12a^tm1Fum/Zc3h12a^tm1Fum C57BL/6-Zc3h12a^tm1Fum	abnormal chemokine secretion	J:176866
	abnormal circulating chemokine level	J:176866
	enlarged lymph nodes	J:176866
	enlarged spleen	J:176866
	increased circulating tumor necrosis factor level	J:176866
	increased interleukin-1 beta secretion	J:176866
	increased interleukin-6 secretion	J:176866
	increased tumor necrosis factor secretion	J:176866
	postnatal growth retardation	J:176866
	premature death	J:176866

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