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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Picalm
phosphatidylinositol binding clathrin assembly protein
MGI:2385902
42 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(cre/ERT2)Thl/0
Picalmtm1.1Tmae/Picalmtm1.1Tmae
involves: 129 * C57BL/6 * SJL 		abnormal erythropoiesis J:220728
diluted coat color J:220728
hypochromic microcytic anemia J:220728
Picalmfit1-494SB/Picalmfit1-494SB
involves: BALB/cRl 		anemia J:100221
decreased body size J:100221
Picalmfit1-764SB/Picalmfit1-764SB
involves: BALB/cRl 		anemia J:100221
decreased body size J:100221
Picalmfit1-3452SB/Picalmfit1-3452SB
involves: BALB/cRl 		anemia J:100221
decreased body size J:100221
Picalmfit1-4226SB/Picalmfit1-4226SB
involves: BALB/cRl 		anemia J:100221
decreased body size J:100221
Picalmfit1-4397SB/Picalmfit1-4397SB
involves: BALB/cRl 		anemia J:100221
decreased body size J:100221
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL 		abnormal iron homeostasis J:220728
decreased CD4-positive, alpha-beta T cell number J:220728
decreased CD8-positive, alpha-beta T cell number J:220728
decreased erythrocyte cell number J:220728
decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
increased circulating erythropoietin level J:220728
microcytic anemia J:220728
reticulocytosis J:220728
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * SJL 		abnormal erythrocyte morphology J:220728
abnormal erythropoiesis J:220728
abnormal iron homeostasis J:220728
decreased CD4-positive, alpha-beta T cell number J:220728
decreased CD8-positive, alpha-beta T cell number J:220728
decreased erythroblast number J:220728
decreased erythrocyte cell number J:220728
decreased hematocrit J:220728
decreased hemoglobin content J:220728
decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
enlarged spleen J:220728
hypochromic microcytic anemia J:220728
impaired hematopoiesis J:220728
increased circulating erythropoietin level J:220728
increased circulating iron level J:220728
increased erythroblast number J:220728
increased red blood cell distribution width J:220728
reticulocytosis J:220728
Picalmtm1.2Tmae/Picalm+
involves: C57BL/6 * FVB/N 		microcytic anemia J:220728
Picalmtm1.2Tmae/Picalmtm1.2Tmae
involves: C57BL/6 * FVB/N 		abnormal embryonic tissue morphology J:220728
abnormal erythropoiesis J:220728
abnormal fetal liver hematopoietic progenitor cell morphology J:220728
decreased embryo size J:220728
decreased erythroblast number J:220728
increased erythroblast number J:220728
lethality throughout fetal growth and development, complete penetrance J:220728
Picalmtm1Towa/Picalmtm1Towa
B6.Cg-Picalmtm1Towa 		lethality, complete penetrance J:185312
Picalmtm1Towa/Picalmtm1Towa
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal B cell differentiation J:185312
abnormal bone marrow cell morphology/development J:185312
abnormal cell physiology J:185312
abnormal erythrocyte physiology J:185312
abnormal erythropoiesis J:185312
abnormal hepatocyte physiology J:185312
abnormal iron homeostasis J:185312
decreased body size J:185312
decreased body weight J:185312
decreased bone marrow cell number J:185312
decreased embryo weight J:185312
decreased erythrocyte cell number J:185312
decreased erythroid progenitor cell number J:185312
decreased hemoglobin content J:185312
decreased mean corpuscular hemoglobin J:185312
decreased spleen B cell follicle number J:185312
enlarged spleen J:185312
fetal growth retardation J:185312
hemosiderosis J:185312
hypochromic microcytic anemia J:185312
postnatal growth retardation J:185312
postnatal lethality, incomplete penetrance J:185312
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory