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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tardbp
TAR DNA binding protein
MGI:2387629
122 phenotypes from 19 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Tardbptm1.1Pcw/Tardbp+
involves: 129 * C57BL/6 * SJL 		abnormal respiratory quotient J:164406
decreased body weight J:164406
decreased total body fat amount J:164406
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Tardbptm1.1Pcw/Tardbptm1.1Pcw
involves: 129 * C57BL/6 * SJL 		abnormal food intake J:164406
abnormal lipid oxidation J:164406
abnormal respiratory quotient J:164406
abnormal survival J:164406
decreased body weight J:164406
decreased total body fat amount J:164406
normal homeostasis/metabolism phenotype J:164406
weight loss J:164406
Mnx1tm4(cre)Tmj/Mnx1+
Tardbptm1.1Ckjs/Tardbptm1.2Cjks
involves: 129S1/Sv * C57BL/6J 		abnormal motor neuron morphology J:190254
abnormal spinal cord ventral horn morphology J:190254
astrocytosis J:190254
decreased body weight J:190254
impaired coordination J:190254
increased microglial cell activation J:190254
kyphosis J:190254
limb grasping J:190254
motor neuron degeneration J:190254
muscle weakness J:190254
muscular atrophy J:190254
premature death J:190254
weight loss J:190254
Tardbpem1Koya/Tardbpem1Koya
C57BL/6J-Tardbpem1Koya 		normal behavior/neurological phenotype J:285477
normal nervous system phenotype J:285477
Tardbpem1Rhbr/Tardbp+
C57BL/6J-Tardbpem1Rhbr 		abnormal learning/memory/conditioning J:261673
abnormal object recognition memory J:261673
decreased stereotypic behavior J:261673
impaired coordination J:261673
Tardbpem1Rhbr/Tardbpem1Rhbr
C57BL/6J-Tardbpem1Rhbr 		abnormal brain interneuron morphology J:261673
abnormal cognition J:261673
abnormal eating behavior J:261673
abnormal GABAergic neuron morphology J:261673
abnormal locomotor behavior J:261673
abnormal object recognition memory J:261673
normal behavior/neurological phenotype J:261673
cognitive inflexibility J:261673
decreased stereotypic behavior J:261673
impaired coordination J:261673
increased body weight J:261673
increased vertical activity J:261673
normal nervous system phenotype J:261673
polyphagia J:261673
preweaning lethality, incomplete penetrance J:261673
TardbpGt(RRB030)Byg/Tardbp+
B6.129P2-TardbpGt(RRB030)Byg 		decreased grip strength J:158641
TardbpGt(RRB030)Byg/TardbpGt(RRB030)Byg
B6.129P2-TardbpGt(RRB030)Byg 		embryonic lethality between implantation and somite formation, complete penetrance J:158641
Tardbpm1H/Tardbp+
involves: C3H/HeH * C57BL/6J 		abnormal muscle tone J:211620
impaired muscle relaxation J:211620
limb grasping J:211620
normal nervous system phenotype J:211620
Tardbpm1H/Tardbpm1H
involves: C3H/HeH * C57BL/6J 		embryonic lethality, complete penetrance J:211620
TardbpRgsc2223/TardbpRgsc2223
C57BL/6J-TardbpRgsc2223 		prenatal lethality, complete penetrance J:265666
TardbpRgsc2223/TardbpRgsc2223
involves: C57BL/6JJcl * DBA/2J 		decreased grip strength J:265666
decreased motor neuron number J:265666
normal mortality/aging J:265666
TardbpRgsc2223/TardbpRgsc2268
involves: C57BL/6JJcl * DBA/2J 		prenatal lethality, incomplete penetrance J:265666
TardbpRgsc2268/TardbpRgsc2268
C57BL/6J-TardbpRgsc2268 		prenatal lethality, complete penetrance J:265666
TardbpRgsc2268/TardbpRgsc2268
involves: C57BL/6JJcl * DBA/2J 		prenatal lethality, complete penetrance J:265666
Tardbptm1.1Ckjs/Tardbptm1.1Ckjs
involves: C57BL/6J * FVB/N 		absent inner cell mass proliferation J:155958
embryonic lethality, complete penetrance J:155958
Tardbptm1.1Hiok/Tardbp+
involves: C57BL/6J 		abnormal cell cycle checkpoint function J:308471
abnormal cerebral cortex morphology J:308471
abnormal endoplasmic reticulum morphology J:308471
abnormal frontal lobe morphology J:308471
abnormal primary motor cortex morphology J:308471
impaired spatial learning J:308471
increased anxiety-related response J:308471
increased body weight J:308471
Tardbptm1.1Jrob/Tardbptm1.1Jrob
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * SJL 		embryonic lethality prior to organogenesis, complete penetrance J:215201
Tardbptm1.1Neas/Tardbp+
B6(C3)-Tardbptm1.1Neas 		normal nervous system phenotype J:283769
Tardbptm1.1Neas/Tardbptm1.1Neas
B6(C3)-Tardbptm1.1Neas 		abnormal motor neuron innervation pattern J:283769
astrocytosis J:283769
microgliosis J:283769
normal nervous system phenotype J:283769
Tardbptm1.1Pcw/Tardbp+
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA * SJL 		abnormal brown fat cell morphology J:164406
abnormal white fat cell morphology J:164406
decreased body weight J:164406
Tardbptm1.1Pcw/Tardbptm1.1Pcw
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA * SJL 		abnormal brown fat cell morphology J:164406
abnormal lipid oxidation J:164406
abnormal white adipose tissue morphology J:164406
abnormal white fat cell morphology J:164406
decreased body weight J:164406
decreased mesenteric fat pad weight J:164406
decreased total body fat amount J:164406
Tardbptm1.1Pcw/Tardbptm1.1Pcw
Tg(Stra8-icre)1Reb/0
involves: C57BL/6 * FVB/NJ * SJL 		abnormal chromosomal synapsis J:324061
abnormal chromosome morphology J:324061
abnormal chromosome number J:324061
abnormal double-strand DNA break repair J:324061
abnormal seminiferous tubule epithelium morphology J:324061
abnormal sperm flagellum morphology J:324061
abnormal sperm head morphology J:324061
absent sperm head J:324061
arrest of male meiosis J:324061
arrest of spermatogenesis J:324061
decreased male germ cell number J:324061
decreased testis weight J:324061
increased male germ cell apoptosis J:324061
oligozoospermia J:324061
reduced male fertility J:324061
seminiferous tubule degeneration J:324061
small seminiferous tubules J:324061
small testis J:324061
teratozoospermia J:324061
Tardbptm1.1Sobue/Tardbptm1.1Sobue
Tg(SLC18A3-cre)Misa/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NTac 		abnormal autophagosome formation J:324570
abnormal motor capabilities/coordination/movement J:324570
abnormal motor neuron morphology J:324570
abnormal neuromuscular synapse morphology J:324570
astrocytosis J:324570
axon degeneration J:324570
decreased grip strength J:324570
impaired coordination J:324570
motor neuron degeneration J:324570
muscular atrophy J:324570
short stride length J:324570
tremors J:324570
weight loss J:324570
Tardbptm1.2Pcw/Tardbptm1.2Pcw
involves: C57BL/6 * SJL 		prenatal lethality, complete penetrance J:164406
Tardbptm1b(EUCOMM)Wtsi/Tardbp+
C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H 		abnormal startle reflex J:211773
decreased blood urea nitrogen level J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased mean platelet volume J:211773
Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Tardbptm2.1Ckjs/Tardbptm2.1Ckjs
involves: C57BL/6J 		normal behavior/neurological phenotype J:285792
normal mortality/aging J:285792
Tardbptm2.1Neas/Tardbp+
B6(C3)-Tardbptm2.1Neas 		normal nervous system phenotype J:283769
Tardbptm2.1Neas/Tardbptm2.1Neas
B6(C3)-Tardbptm2.1Neas 		abnormal motor neuron innervation pattern J:283769
astrocytosis J:283769
microgliosis J:283769
motor neuron degeneration J:283769
normal nervous system phenotype J:283769
Tardbptm3.1Ckjs/Tardbp+
involves: C57BL/6J 		abnormal motor capabilities/coordination/movement J:285792
abnormal motor neuron morphology J:285792
abnormal neuromuscular synapse morphology J:285792
astrocytosis J:285792
hindlimb paralysis J:285792
impaired coordination J:285792
kyphosis J:285792
limb grasping J:285792
motor neuron degeneration J:285792
neuronal cytoplasmic inclusions J:285792
premature death J:285792
skeletal muscle atrophy J:285792
spasticity J:285792
tremors J:285792
weight loss J:285792
Tardbptm3.1Ckjs/Tardbp+
Tg(Hlxb9-GFP)1Tmj/0
involves: C57BL/6 * C57BL/6J * CBA 		abnormal axon morphology J:285792
abnormal calcium ion homeostasis J:285792
abnormal motor neuron morphology J:285792
Tardbptm3.1Ckjs/Tardbptm3.1Ckjs
involves: C57BL/6J 		postnatal lethality, complete penetrance J:285792
Tg(Camk2a-Tardbp)#Ckjs/0
FVB/N-Tg(Camk2a-Tardbp)#Ckjs 		abnormal spatial learning J:163612
Tg(Camk2a-Tardbp)#Ckjs/Tg(Camk2a-Tardbp)#Ckjs
FVB/N-Tg(Camk2a-Tardbp)#Ckjs 		abnormal miniature excitatory postsynaptic currents J:163612
abnormal motor capabilities/coordination/movement J:163612
abnormal neuron morphology J:163612
abnormal spatial learning J:163612
decreased brain weight J:163612
decreased hippocampus volume J:163612
decreased neuron number J:163612
gliosis J:163612
impaired contextual conditioning behavior J:163612
impaired coordination J:163612
impaired short-term object recognition memory J:163612
increased neuron apoptosis J:163612
limb grasping J:163612
neurodegeneration J:163612
premature death J:163612
reduced long-term potentiation J:163612
Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu/0
involves: C57BL/6 * C57BL/6J * FVB/NJ * SJL 		abnormal gait J:207750
abnormal muscle morphology J:207750
astrocytosis J:207750
axon degeneration J:207750
decreased locomotor activity J:207750
decreased vertical activity J:207750
enlarged heart J:207750
head bobbing J:207750
hindlimb paralysis J:207750
hyperactivity J:207750
impaired limb coordination J:207750
microgliosis J:207750
motor neuron degeneration J:207750
muscle degeneration J:207750
neurodegeneration J:207750
paralysis J:207750
premature death J:207750
progressive muscle weakness J:207750
skeletal muscle fiber necrosis J:207750
weight loss J:207750
Tg(CAG-EGFP,-dsRed2/RNAi:Tardbp)6Zxu/0
involves: C57BL/6 * SJL 		normal behavior/neurological phenotype J:207750
normal mortality/aging J:207750
Tg(CAG-EGFP,-dsRed2/RNAi:Tardbp)6Zxu/0
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		microcephaly J:207750
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory