Clrn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Clrn1
clarin 1
MGI:2388124

42 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal auditory brainstem response	J:211773
	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal lung morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal startle reflex	J:211773
	abnormal vibrissa morphology	J:211773
Clrn1^tm1.1Kuna/Clrn1^tm1.1Kuna involves: C57BL/6J	abnormal auditory brainstem response waveform shape	J:150215
	abnormal cochlear hair cell physiology	J:186316
	abnormal cochlear hair cell stereociliary bundle morphology	J:186316
	abnormal inner hair cell stereociliary bundle morphology	J:255408
	abnormal orientation of outer hair cell stereociliary bundles	J:150215
	abnormal outer hair cell stereociliary bundle morphology	J:150215, J:255408
	abnormal vestibular hair cell physiology	J:186316
	absent cochlear inner hair cells	J:150215
	absent cochlear outer hair cells	J:150215
	absent distortion product otoacoustic emissions	J:150215
	deafness	J:150215
	decreased cochlear microphonics	J:186316
	degeneration of organ of Corti supporting cells	J:150215
	head bobbing	J:150215
	normal hearing/vestibular/ear phenotype	J:150215, J:186316
	impaired balance	J:150215
	impaired hearing	J:150215, J:255408
	increased or absent threshold for auditory brainstem response	J:150215
	organ of Corti degeneration	J:150215
	reduced linear vestibular evoked potential	J:150215
	normal vision/eye phenotype	J:150215
Clrn1^tm1.1Kuna/Clrn1^tm1.1Kuna Tg(Atoh1-Clrn1)#Kuna/0 involves: C57BL/6J	abnormal inner hair cell stereociliary bundle morphology	J:255408
	abnormal outer hair cell stereociliary bundle morphology	J:255408
	impaired hearing	J:255408
Clrn1^tm1.1Ugpa/Clrn1^tm1.1Ugpa Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ involves: 129S1/SvImJ * C57BL/6N	abnormal cochlear IHC afferent innervation pattern	J:265318
	abnormal cochlear inner hair cell physiology	J:265318
	abnormal cochlear nerve compound action potential	J:265318
	abnormal cochlear nerve fiber response	J:265318
	abnormal cochlear nerve morphology	J:265318
	abnormal inner hair cell stereociliary bundle morphology	J:265318
	abnormal outer hair cell stereociliary bundle morphology	J:265318
	abnormal ribbon synapse morphology	J:265318
	abnormal synapse morphology	J:265318
	abnormal synaptic vesicle exocytosis	J:265318
	cochlear inner hair cell degeneration	J:265318
	cochlear outer hair cell degeneration	J:265318
	deafness	J:265318
	increased or absent distortion product otoacoustic emission threshold	J:265318
	increased or absent threshold for auditory brainstem response	J:265318
	sensorineural hearing loss	J:265318
Clrn1^tm1.2Ugpa/Clrn1^tm1.2Ugpa involves: BALB/c * C57BL/6 * C57BL/6N	abnormal cochlear hair cell stereociliary bundle morphology	J:265318
	abnormal cochlear IHC afferent innervation pattern	J:265318
	abnormal cochlear inner hair cell physiology	J:265318
	abnormal cochlear nerve fiber response	J:265318
	abnormal cochlear nerve morphology	J:265318
	abnormal inner hair cell stereociliary bundle morphology	J:265318
	abnormal outer hair cell stereociliary bundle morphology	J:265318
	abnormal ribbon synapse morphology	J:265318
	abnormal synapse morphology	J:265318
	abnormal synaptic vesicle exocytosis	J:265318
	absent distortion product otoacoustic emissions	J:265318
	cochlear ganglion degeneration	J:265318
	deafness	J:265318
	increased or absent threshold for auditory brainstem response	J:265318
Clrn1^tm2.1Kuna/Clrn1^tm2.1Kuna involves: 129 * BALB/cJ * C57BL/6J	abnormal cochlear hair cell stereociliary bundle morphology	J:186316
	deafness	J:186316
	increased or absent threshold for auditory brainstem response	J:186316
Clrn1^tm2.1Kuna/Clrn1^tm2.1Kuna involves: 129 * C57BL/6J	deafness	J:260239
Clrn1^tm2.1Kuna/Clrn1^tm2.1Kuna Tg(Atoh1-Clrn1)#Kuna/0 involves: 129 * C57BL/6J	deafness	J:260239
	increased or absent threshold for auditory brainstem response	J:260239

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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