Pkn3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pkn3
protein kinase N3
MGI:2388285

8 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Pkn1^tm1Ajmc/Pkn1^tm1Ajmc Pkn2^{tm1a(KOMP)Wtsi}/Pkn2⁺ Pkn3^tm1Ajmc/Pkn3^tm1Ajmc involves: 129P2/OlaHsd * C57BL/6N * C57BL/6NTac	no abnormal phenotype detected	J:229595
Pkn1^tm1Ajmc/Pkn1^tm1Ajmc Pkn3^tm1Ajmc/Pkn3^tm1Ajmc involves: 129P2/OlaHsd * C57BL/6NTac	no abnormal phenotype detected	J:229595
Pkn3^tm1.1Mrl/Pkn3⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA/J	enlarged spleen	J:216983
	enlarged thymus	J:216983
	extramedullary hematopoiesis	J:216983
	increased acute lymphoblastic leukemia incidence	J:216983
	increased hemolymphoid system tumor incidence	J:216983
	premature death	J:216983
Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Pten^tm1Hwu/Pten^tm1Hwu Tg(CD2-icre)4Kio/0 involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca	normal endocrine/exocrine gland phenotype	J:216983
Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Pten^tm1Hwu/Pten^tm1Hwu Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA/J	enlarged spleen	J:216983
	enlarged thymus	J:216983
	extramedullary hematopoiesis	J:216983
	increased acute lymphoblastic leukemia incidence	J:216983
	increased hemolymphoid system tumor incidence	J:216983
	premature death	J:216983

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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