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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irak2
interleukin-1 receptor-associated kinase 2
MGI:2429603
12 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irak2tm1.1Pcoh/?
involves: C57BL/6 		decreased interferon-alpha secretion J:205798
Irak2tm1Aki/Irak2tm1Aki
involves: 129/Sv * C57BL/6 		abnormal macrophage physiology J:136290
decreased susceptibility to endotoxin shock J:136290
Irak2tm1b(EUCOMM)Wtsi/Irak2tm1b(EUCOMM)Wtsi
C57BL/6N-Irak2tm1b(EUCOMM)Wtsi/H 		increased circulating alkaline phosphatase level J:211773
increased total body fat amount J:211773
short tibia J:211773
Irak2tm1Jth/Irak2tm1Jth
involves: 129 * C57BL/6 		abnormal chemokine level J:149258
decreased circulating interleukin-6 level J:149258
decreased circulating tumor necrosis factor level J:149258
decreased interleukin-6 secretion J:149258
decreased susceptibility to endotoxin shock J:149258
decreased susceptibility to induced morbidity/mortality J:149258
decreased tumor necrosis factor secretion J:149258
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory