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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbc1d4
TBC1 domain family, member 4
MGI:2429660
32 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tbc1d4tm1.1Arte/Tbc1d4tm1.1Arte
involves: C57BL/6 		decreased body size J:169477
decreased muscle cell glucose uptake J:169477
decreased spleen weight J:169477
impaired glucose tolerance J:169477
increased adipocyte glucose uptake J:169477
increased heart weight J:169477
increased muscle cell glucose uptake J:169477
increased testis weight J:169477
insulin resistance J:169477
Tbc1d4tm1.1Arte/Tbc1d4tm1.1Arte
Not Specified 		normal homeostasis/metabolism phenotype J:186867
normal muscle phenotype J:186867
Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
involves: C57BL/6 * CBA 		abnormal gluconeogenesis J:194026
abnormal glucose homeostasis J:194026
decreased adipocyte glucose uptake J:194026
decreased adiponectin level J:194026
decreased basal metabolism J:194026
decreased circulating glucose level J:194026
decreased circulating insulin level J:194026
decreased energy expenditure J:194026
decreased oxygen consumption J:194026
decreased skeletal muscle cell glucose uptake J:194026
impaired glucose tolerance J:194026
increased adipocyte glucose uptake J:194026
increased circulating free fatty acids level J:194026
insulin resistance J:194026
Tbc1d4tm1b(EUCOMM)Hmgu/Tbc1d4tm1b(EUCOMM)Hmgu
C57BL/6N-Tbc1d4tm1b(EUCOMM)Hmgu/J 		decreased circulating chloride level J:211773
decreased leukocyte cell number J:211773
increased circulating sodium level J:211773
increased hematocrit J:211773
increased mean corpuscular volume J:211773
Tbc1d4tm1Lex/Tbc1d4tm1Lex
involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N 		abnormal glycogen homeostasis J:191749
decreased adipocyte glucose uptake J:191749
decreased circulating glucose level J:191749
decreased circulating insulin level J:191749
decreased skeletal muscle cell glucose uptake J:191749
impaired glucose tolerance J:191749
increased adipocyte glucose uptake J:191749
increased epididymal fat pad weight J:191749
increased parametrial fat pad weight J:191749
increased white fat cell size J:191749
insulin resistance J:191749
lethality, incomplete penetrance J:191749
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory