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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trpv5
transient receptor potential cation channel, subfamily V, member 5
MGI:2429764
28 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Trpv5Hcalc1/Trpv5+
involves: C3H/HeH * C57BL/6J 		abnormal kidney morphology J:196612
abnormal renal tubule epithelium morphology J:196612
abnormal renal tubule morphology J:196612
dilated renal tubule J:196612
normal homeostasis/metabolism phenotype J:196612
increased renal tubule apoptosis J:196612
increased urine calcium level J:196612
kidney inflammation J:196612
renal interstitial fibrosis J:196612
small kidney J:196612
Trpv5Hcalc1/Trpv5Hcalc1
involves: C3H/HeH * C57BL/6J 		abnormal bone structure J:196612
abnormal kidney morphology J:196612
abnormal renal tubule epithelium morphology J:196612
abnormal renal tubule morphology J:196612
abnormal vitamin D level J:196612
decreased circulating calcium level J:196612
decreased circulating phosphate level J:196612
decreased trabecular bone thickness J:196612
decreased urine pH J:196612
dilated renal tubule J:196612
normal homeostasis/metabolism phenotype J:196612
increased renal tubule apoptosis J:196612
increased urine calcium level J:196612
increased urine phosphate level J:196612
kidney inflammation J:196612
polydipsia J:196612
polyuria J:196612
renal interstitial fibrosis J:196612
small kidney J:196612
Trpv5m1Btlr/Trpv5m1Btlr
C57BL/6J-Trpv5m1Btlr 		diarrhea J:192586
increased susceptibility to induced colitis J:192586
intestinal inflammation J:192586
polydipsia J:192586
polyuria J:192586
weight loss J:192586
Trpv5tm1Bind/Trpv5tm1Bind
involves: 129 * C57BL/6 		abnormal bone structure J:86949
abnormal calcium ion homeostasis J:86949
abnormal long bone diaphysis morphology J:86949
abnormal renal calcium reabsorption J:86949
abnormal vitamin D level J:86949
decreased compact bone thickness J:86949
decreased trabecular bone thickness J:86949
decreased urine pH J:86949
normal homeostasis/metabolism phenotype J:86949
increased osteoclast cell number J:86949
increased urine calcium level J:86949
increased urine phosphate level J:86949
polyuria J:86949
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory