Dock1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dock1
dedicator of cytokinesis 1
MGI:2429765

31 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dock1^b2b3190Clo/Dock1^b2b3190Clo C57BL/6J-Dock1^b2b3190Clo	atrioventricular septal defect	J:175213
	double outlet right ventricle	J:175213
	hydronephrosis	J:175213
	hydrops fetalis	J:175213
	micrognathia	J:175213
	persistent truncus arteriosus	J:175213
	pulmonary valve atresia	J:175213
	short snout	J:175213
	thymus hypoplasia	J:175213
	ventricular septal defect	J:175213
Dock1^tm1.1Ysfk/Dock1^tm1.1Ysfk B6(Cg)-Dock1^tm1.1Ysfk	abnormal heart morphology	J:178190
	abnormal heart right ventricle outflow tract morphology	J:178190
	abnormal myogenesis	J:178190
	abnormal vascular endothelial cell migration	J:178190
	abnormal vasculogenesis	J:178190
	edema	J:178190
	lethality throughout fetal growth and development, incomplete penetrance	J:178190
	prenatal lethality, complete penetrance	J:178190
	thick mitral valve cusps	J:178190
	ventricular septal defect	J:178190
Dock1^tm1Jfco/Dock1^tm1Jfco involves: 129	abnormal heart right ventricle outflow tract morphology	J:178190
	abnormal myogenesis	J:178190
	edema	J:178190
	thick mitral valve cusps	J:178190
	ventricular septal defect	J:178190
Dock1^tm1Jfco/Dock1^tm1Jfco involves: 129/Sv * C57BL/6	abnormal diaphragm morphology	J:143342
	abnormal intercostal muscle morphology	J:143342
	abnormal muscle development	J:143342
	abnormal muscle physiology	J:143342
	atelectasis	J:143342
	cyanosis	J:143342
	decreased birth body size	J:143342
	decreased skeletal muscle fiber diameter	J:143342
	decreased skeletal muscle mass	J:143342
	lethality at weaning, complete penetrance	J:143342
	thin diaphragm muscle	J:143342
Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-cre)7Mul/0 involves: C57BL/6 * FVB/N * FVB/NJ	normal endocrine/exocrine gland phenotype	J:196659

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24