Dock1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dock1
dedicator of cytokinesis 1
MGI:2429765

31 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dock1^b2b3190Clo/Dock1^b2b3190Clo C57BL/6J-Dock1^b2b3190Clo	atrioventricular septal defect	J:175213
	double outlet right ventricle	J:175213
	hydronephrosis	J:175213
	hydrops fetalis	J:175213
	micrognathia	J:175213
	persistent truncus arteriosus	J:175213
	pulmonary valve atresia	J:175213
	short snout	J:175213
	thymus hypoplasia	J:175213
	ventricular septal defect	J:175213
Dock1^tm1.1Ysfk/Dock1^tm1.1Ysfk B6(Cg)-Dock1^tm1.1Ysfk	abnormal heart morphology	J:178190
	abnormal heart right ventricle outflow tract morphology	J:178190
	abnormal myogenesis	J:178190
	abnormal vascular endothelial cell migration	J:178190
	abnormal vasculogenesis	J:178190
	edema	J:178190
	lethality throughout fetal growth and development, incomplete penetrance	J:178190
	prenatal lethality, complete penetrance	J:178190
	thick mitral valve cusps	J:178190
	ventricular septal defect	J:178190
Dock1^tm1Jfco/Dock1^tm1Jfco involves: 129	abnormal heart right ventricle outflow tract morphology	J:178190
	abnormal myogenesis	J:178190
	edema	J:178190
	thick mitral valve cusps	J:178190
	ventricular septal defect	J:178190
Dock1^tm1Jfco/Dock1^tm1Jfco involves: 129/Sv * C57BL/6	abnormal diaphragm morphology	J:143342
	abnormal intercostal muscle morphology	J:143342
	abnormal muscle development	J:143342
	abnormal muscle physiology	J:143342
	atelectasis	J:143342
	cyanosis	J:143342
	decreased birth body size	J:143342
	decreased skeletal muscle fiber diameter	J:143342
	decreased skeletal muscle mass	J:143342
	lethality at weaning, complete penetrance	J:143342
	thin diaphragm muscle	J:143342
Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-cre)7Mul/0 involves: C57BL/6 * FVB/N * FVB/NJ	normal endocrine/exocrine gland phenotype	J:196659

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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