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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dock1
dedicator of cytokinesis 1
MGI:2429765
11 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dock1tm1Jfco/Dock1+
Dock5Gt(AN0268)Wtsi/Dock5+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		normal muscle phenotype J:143342
Dock1tm1Jfco/Dock1+
Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		decreased skeletal muscle fiber diameter J:143342
Dock1tm1Jfco/Dock1tm1Jfco
Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal embryo development J:143342
lethality throughout fetal growth and development, complete penetrance J:143342
Dock1tm2.1Jfco/Dock1+
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: C57BL/6 * FVB/NJ 		increased mammary adenocarcinoma incidence J:196659
increased mammary gland tumor incidence J:196659
increased tumor latency J:196659
Dock1tm2.1Jfco/Dock1tm2.1Jfco
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: C57BL/6 * FVB/NJ 		decreased cell proliferation J:196659
decreased metastatic potential J:196659
decreased tumor growth/size J:196659
increased apoptosis J:196659
increased mammary adenocarcinoma incidence J:196659
increased mammary gland tumor incidence J:196659
increased tumor latency J:196659
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory